Cytotoxic and Leishmanicidal Aminoglycosteroids and Aminosteroids from Holarrhena curtisii
Toh Seok Kam
1
,
Kooi-Mow Sim
1
,
Takashi Koyano
1
,
Mitsuhide Toyoshima
1
,
Masahiko Hayashi
1
,
Kanki Komiyama
1
1
Department of Chemistry, University of Malaya, 59100 Kuala Lumpur, Malaysia, Temko Corporation, 4-27-4 Honcho, Nakano, Tokyo 164, Japan, and The Kitasato Institute, 5-9-1 Shirokane, Minato-ku, Tokyo 108, Japan
|
Publication type: Journal Article
Publication date: 1998-10-02
scimago Q1
wos Q1
SJR: 0.629
CiteScore: 6.5
Impact factor: 3.6
ISSN: 01633864, 15206025
PubMed ID:
9834146
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
The EtOH extract of the leaves of Holarrhena curtisii yielded five new steroidal alkaloids: 17-epi-holacurtine (3), 17-epi-N-demethylholacurtine (4), holacurtinol (5), 3alpha-amino-14beta-hydroxypregnan-20-one (7), and 15alpha-hydroxyholamine (8), in addition to the known compounds, holacurtine (1), N-demethylholacurtine (2), and holamine (6). All eight compounds showed significant cytotoxic and leishmanicidal activities.
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49
Total citations:
49
Citations from 2024:
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(10%)
Cite this
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RIS |
BibTex |
MLA
Cite this
GOST
Copy
Kam T. S. et al. Cytotoxic and Leishmanicidal Aminoglycosteroids and Aminosteroids from Holarrhena curtisii // Journal of Natural Products. 1998. Vol. 61. No. 11. pp. 1332-1336.
GOST all authors (up to 50)
Copy
Kam T. S., Sim K., Koyano T., Toyoshima M., Hayashi M., Komiyama K. Cytotoxic and Leishmanicidal Aminoglycosteroids and Aminosteroids from Holarrhena curtisii // Journal of Natural Products. 1998. Vol. 61. No. 11. pp. 1332-1336.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/np970545f
UR - https://doi.org/10.1021/np970545f
TI - Cytotoxic and Leishmanicidal Aminoglycosteroids and Aminosteroids from Holarrhena curtisii
T2 - Journal of Natural Products
AU - Kam, Toh Seok
AU - Sim, Kooi-Mow
AU - Koyano, Takashi
AU - Toyoshima, Mitsuhide
AU - Hayashi, Masahiko
AU - Komiyama, Kanki
PY - 1998
DA - 1998/10/02
PB - American Chemical Society (ACS)
SP - 1332-1336
IS - 11
VL - 61
PMID - 9834146
SN - 0163-3864
SN - 1520-6025
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1998_Kam,
author = {Toh Seok Kam and Kooi-Mow Sim and Takashi Koyano and Mitsuhide Toyoshima and Masahiko Hayashi and Kanki Komiyama},
title = {Cytotoxic and Leishmanicidal Aminoglycosteroids and Aminosteroids from Holarrhena curtisii},
journal = {Journal of Natural Products},
year = {1998},
volume = {61},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/np970545f},
number = {11},
pages = {1332--1336},
doi = {10.1021/np970545f}
}
Cite this
MLA
Copy
Kam, Toh Seok, et al. “Cytotoxic and Leishmanicidal Aminoglycosteroids and Aminosteroids from Holarrhena curtisii.” Journal of Natural Products, vol. 61, no. 11, Oct. 1998, pp. 1332-1336. https://doi.org/10.1021/np970545f.