Organic Letters, volume 4, issue 17, pages 2905-2907

Ethyl 2-Chlorooxazole-4-carboxylate: A Versatile Intermediate for the Synthesis of Substituted Oxazoles

Kevin J. Hodgetts ¹

Mark T Kershaw ¹

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Neurogen Corporation, 35 Northeast Industrial Road, Branford, Connecticut 06405 |

Publication type: Journal Article

Publication date: 2002-07-23

American Chemical Society (ACS)

Journal: Organic Letters

scimago Q1

SJR: 1.245

CiteScore: 9.3

Impact factor: 4.9

ISSN: 15237060, 15237052

DOI: 10.1021/ol0262800

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PubMed ID: 12182585

Organic Chemistry

Biochemistry

Physical and Theoretical Chemistry

Abstract

[reaction: see text] By using a sequence of regiocontrolled halogenation and palladium-catalyzed coupling reactions, the synthesis of variously substituted oxazoles from ethyl 2-chlorooxazole-4-carboxylate (2) was accomplished. The methodology was applied to the synthesis of a series of 2,4-disubstituted, 2,5-disubstituted, and 2,4,5-trisubstituted oxazoles.

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CITATIONS

63 Total citations

3 Recent citations

6.39 Field Citation Ratio

0.79 Relative Citation Ratio

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Hodgetts K. J., Kershaw M. T. Ethyl 2-Chlorooxazole-4-carboxylate: A Versatile Intermediate for the Synthesis of Substituted Oxazoles // Organic Letters. 2002. Vol. 4. No. 17. pp. 2905-2907.

GOST all authors (up to 50) Copy

Hodgetts K. J., Kershaw M. T. Ethyl 2-Chlorooxazole-4-carboxylate: A Versatile Intermediate for the Synthesis of Substituted Oxazoles // Organic Letters. 2002. Vol. 4. No. 17. pp. 2905-2907.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/ol0262800

UR - https://doi.org/10.1021/ol0262800

TI - Ethyl 2-Chlorooxazole-4-carboxylate: A Versatile Intermediate for the Synthesis of Substituted Oxazoles

T2 - Organic Letters

AU - Hodgetts, Kevin J.

AU - Kershaw, Mark T

PY - 2002

DA - 2002/07/23

PB - American Chemical Society (ACS)

SP - 2905-2907

IS - 17

VL - 4

PMID - 12182585

SN - 1523-7060

SN - 1523-7052

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2002_Hodgetts,

author = {Kevin J. Hodgetts and Mark T Kershaw},

title = {Ethyl 2-Chlorooxazole-4-carboxylate: A Versatile Intermediate for the Synthesis of Substituted Oxazoles},

journal = {Organic Letters},

year = {2002},

volume = {4},

publisher = {American Chemical Society (ACS)},

month = {jul},

url = {https://doi.org/10.1021/ol0262800},

number = {17},

pages = {2905--2907},

doi = {10.1021/ol0262800}

}

MLA

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MLA Copy

Hodgetts, Kevin J., and Mark T Kershaw. “Ethyl 2-Chlorooxazole-4-carboxylate: A Versatile Intermediate for the Synthesis of Substituted Oxazoles.” Organic Letters, vol. 4, no. 17, Jul. 2002, pp. 2905-2907. https://doi.org/10.1021/ol0262800.

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Publisher

American Chemical Society (ACS)

Journal

Organic Letters

scimago Q1

SJR

1.245

CiteScore

9.3

Impact factor

4.9

ISSN

15237060 (Print)

15237052 (Electronic)