, том 15 , издание 18 , страницы 4766-4769

Construction of Multifunctional Modules for Drug Discovery: Synthesis of Novel Thia/Oxa-Azaspiro[3.4]octanes

Dong-bo LI ¹

Mark Rogers-Evans ¹

Scott Miller ¹

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Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland, and Discovery Research, Chemistry Technologies & Innovation, F. Hoffmann-La Roche AG, CH-4070 Basel, Switzerland

Швейцарская высшая техническая школа Цюриха

Холдинг Рош

Тип публикации: Journal Article

Дата публикации: 2013-08-30

American Chemical Society (ACS)

Organic Letters

scimago Q1

wos Q1

БС1

SJR: 1.235

CiteScore: 8.7

Impact factor: 5.0

ISSN: 15237060, 15237052

DOI: 10.1021/ol402127b

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PubMed ID: 23991674

Organic Chemistry

Biochemistry

Physical and Theoretical Chemistry

Краткое описание

New classes of thia/oxa-azaspiro[3.4]octanes are synthesized through the implementation of robust and step-economic routes. The targeted spirocycles have been designed to act as novel, multifunctional, and structurally diverse modules for drug discovery. Furthermore, enantioselective approaches to the spirocycles are reported.

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LI D., Rogers-Evans M., Miller S. Construction of Multifunctional Modules for Drug Discovery: Synthesis of Novel Thia/Oxa-Azaspiro[3.4]octanes // Organic Letters. 2013. Vol. 15. No. 18. pp. 4766-4769.

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TY - JOUR

DO - 10.1021/ol402127b

UR - https://doi.org/10.1021/ol402127b

TI - Construction of Multifunctional Modules for Drug Discovery: Synthesis of Novel Thia/Oxa-Azaspiro[3.4]octanes

T2 - Organic Letters

AU - LI, Dong-bo

AU - Rogers-Evans, Mark

AU - Miller, Scott

PY - 2013

DA - 2013/08/30

PB - American Chemical Society (ACS)

SP - 4766-4769

IS - 18

VL - 15

PMID - 23991674

SN - 1523-7060

SN - 1523-7052

ER -

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@article{2013_LI,

author = {Dong-bo LI and Mark Rogers-Evans and Scott Miller},

title = {Construction of Multifunctional Modules for Drug Discovery: Synthesis of Novel Thia/Oxa-Azaspiro[3.4]octanes},

journal = {Organic Letters},

year = {2013},

volume = {15},

publisher = {American Chemical Society (ACS)},

month = {aug},

url = {https://doi.org/10.1021/ol402127b},

number = {18},

pages = {4766--4769},

doi = {10.1021/ol402127b}

}

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LI, Dong-bo, et al. “Construction of Multifunctional Modules for Drug Discovery: Synthesis of Novel Thia/Oxa-Azaspiro[3.4]octanes.” Organic Letters, vol. 15, no. 18, Aug. 2013, pp. 4766-4769. https://doi.org/10.1021/ol402127b.

Издатель

American Chemical Society (ACS)

Журнал

Organic Letters

scimago Q1

wos Q1

БС1

SJR

1.235

CiteScore

8.7

Impact factor

5.0

ISSN

15237060 (Print)

15237052 (Electronic)