Activation of Mg Metal for Safe Formation of Grignard Reagents on Plant Scale
1
Process Research, Schering AG, Process Research, D-13342 Berlin, Germany
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Publication type: Journal Article
Publication date: 2002-10-24
scimago Q1
wos Q1
SJR: 0.865
CiteScore: 5.4
Impact factor: 3.5
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
A general and reliable method for the activation of magnesium metal for the formation of various kinds of Grignard reagents has been developed. Utilizing diisobutylaluminum hydride (DIBAH) for the activation of the surface and drying of the reaction mixture the initiation of the Grignard reagent formation can be performed at or below 20 °C for aryl Grignard reagents. For alkyl bromides it is possible to activate the magnesium turnings at even lower temperatures. As the temperature is well below the boiling point of THF, it is possible to detect the initiation of the reaction through the temperature rise. The initiation method was found to be reliable also under very diluted reaction conditions as long as the reaction mixture was stirred. We have also shown that with this method it is possible to manufacture Grignard reagents well below the boiling point of THF.
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Metrics
74
Total citations:
74
Citations from 2024:
7
(9.46%)
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MLA
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GOST
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Tilstam U., Weinmann H. Activation of Mg Metal for Safe Formation of Grignard Reagents on Plant Scale // Organic Process Research and Development. 2002. Vol. 6. No. 6. pp. 906-910.
GOST all authors (up to 50)
Copy
Tilstam U., Weinmann H. Activation of Mg Metal for Safe Formation of Grignard Reagents on Plant Scale // Organic Process Research and Development. 2002. Vol. 6. No. 6. pp. 906-910.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/op025567+
UR - https://doi.org/10.1021/op025567
TI - Activation of Mg Metal for Safe Formation of Grignard Reagents on Plant Scale
T2 - Organic Process Research and Development
AU - Tilstam, Ulf
AU - Weinmann, Hilmar
PY - 2002
DA - 2002/10/24
PB - American Chemical Society (ACS)
SP - 906-910
IS - 6
VL - 6
SN - 1083-6160
SN - 1520-586X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2002_Tilstam,
author = {Ulf Tilstam and Hilmar Weinmann},
title = {Activation of Mg Metal for Safe Formation of Grignard Reagents on Plant Scale},
journal = {Organic Process Research and Development},
year = {2002},
volume = {6},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/op025567 },
number = {6},
pages = {906--910},
doi = {10.1021/op025567+}
}
Cite this
MLA
Copy
Tilstam, Ulf, and Hilmar Weinmann. “Activation of Mg Metal for Safe Formation of Grignard Reagents on Plant Scale.” Organic Process Research and Development, vol. 6, no. 6, Oct. 2002, pp. 906-910. https://doi.org/10.1021/op025567 .