Biomacromolecules, volume 22, issue 2, pages 681-689

Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media

Publication typeJournal Article
Publication date2020-12-16
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor6.2
ISSN15257797, 15264602
Materials Chemistry
Polymers and Plastics
Bioengineering
Biomaterials
Abstract
We report here the first evidence for the interaction of poly(ethylene glycol) (PEG) with hyaluronan (HA) in aqueous solutions. PEG–HA complexes (Kapp = 45,000 ± 8000 M–1) contained about 3.3 ± 0.1 of ethylene glycol units per disaccharide of HA. The carboxyl of the D-glucuronic acid and the amide of the N-acetyl-D-glucosamine did not participate in PEG binding. Similar experiments performed with dextran and monosaccharides showed that multiple free primary hydroxyls regularly distributed along the polysaccharide chain are necessary for PEG binding. Another novelty of our study is contraction of HA upon PEG binding. The effect was observed with HA in solution or adsorbed on positively charged liposomes. The thickness of the HA layer on the liposomes decreased 2-fold upon PEG addition. HA compaction induced by PEG may underlie the changes in the plasma membrane properties and resealing of mechanical injuries induced by Pluronics.

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Le Deygen I. M. et al. Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media // Biomacromolecules. 2020. Vol. 22. No. 2. pp. 681-689.
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Le Deygen I. M., Musatova O. E., Orlov V., Melik-Nubarov N. S., Grozdova I. D. Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media // Biomacromolecules. 2020. Vol. 22. No. 2. pp. 681-689.
RIS |
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TY - JOUR
DO - 10.1021/acs.biomac.0c01504
UR - https://doi.org/10.1021%2Facs.biomac.0c01504
TI - Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media
T2 - Biomacromolecules
AU - Musatova, Oxana E
AU - Le Deygen, Irina M
AU - Melik-Nubarov, Nikolay S.
AU - Orlov, Victor
AU - Grozdova, Irina D
PY - 2020
DA - 2020/12/16 00:00:00
PB - American Chemical Society (ACS)
SP - 681-689
IS - 2
VL - 22
SN - 1525-7797
SN - 1526-4602
ER -
BibTex |
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BibTex Copy
@article{2020_Le Deygen
author = {Oxana E Musatova and Irina M Le Deygen and Nikolay S. Melik-Nubarov and Victor Orlov and Irina D Grozdova},
title = {Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media},
journal = {Biomacromolecules},
year = {2020},
volume = {22},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021%2Facs.biomac.0c01504},
number = {2},
pages = {681--689},
doi = {10.1021/acs.biomac.0c01504}
}
MLA
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MLA Copy
Le Deygen, Irina M., et al. “Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media.” Biomacromolecules, vol. 22, no. 2, Dec. 2020, pp. 681-689. https://doi.org/10.1021%2Facs.biomac.0c01504.
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