Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media
Publication type: Journal Article
Publication date: 2020-12-16
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 9.2
Impact factor: 5.4
ISSN: 15257797, 15264602
PubMed ID:
33325680
Materials Chemistry
Polymers and Plastics
Bioengineering
Biomaterials
Abstract
We report here the first evidence for the interaction of poly(ethylene glycol) (PEG) with hyaluronan (HA) in aqueous solutions. PEG–HA complexes (Kapp = 45,000 ± 8000 M–1) contained about 3.3 ± 0.1 of ethylene glycol units per disaccharide of HA. The carboxyl of the D-glucuronic acid and the amide of the N-acetyl-D-glucosamine did not participate in PEG binding. Similar experiments performed with dextran and monosaccharides showed that multiple free primary hydroxyls regularly distributed along the polysaccharide chain are necessary for PEG binding. Another novelty of our study is contraction of HA upon PEG binding. The effect was observed with HA in solution or adsorbed on positively charged liposomes. The thickness of the HA layer on the liposomes decreased 2-fold upon PEG addition. HA compaction induced by PEG may underlie the changes in the plasma membrane properties and resealing of mechanical injuries induced by Pluronics.
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GOST
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Le Deygen I. M. et al. Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media // Biomacromolecules. 2020. Vol. 22. No. 2. pp. 681-689.
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Le Deygen I. M., Musatova O. E., Orlov V., Melik-Nubarov N. S., Grozdova I. D. Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media // Biomacromolecules. 2020. Vol. 22. No. 2. pp. 681-689.
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RIS
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TY - JOUR
DO - 10.1021/acs.biomac.0c01504
UR - https://doi.org/10.1021/acs.biomac.0c01504
TI - Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media
T2 - Biomacromolecules
AU - Le Deygen, Irina M
AU - Musatova, Oxana E
AU - Orlov, Victor
AU - Melik-Nubarov, Nikolay S.
AU - Grozdova, Irina D
PY - 2020
DA - 2020/12/16
PB - American Chemical Society (ACS)
SP - 681-689
IS - 2
VL - 22
PMID - 33325680
SN - 1525-7797
SN - 1526-4602
ER -
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BibTex (up to 50 authors)
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@article{2020_Le Deygen,
author = {Irina M Le Deygen and Oxana E Musatova and Victor Orlov and Nikolay S. Melik-Nubarov and Irina D Grozdova},
title = {Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media},
journal = {Biomacromolecules},
year = {2020},
volume = {22},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/acs.biomac.0c01504},
number = {2},
pages = {681--689},
doi = {10.1021/acs.biomac.0c01504}
}
Cite this
MLA
Copy
Le Deygen, Irina M., et al. “Poly(Ethylene Glycol) Interacts with Hyaluronan in Aqueous Media.” Biomacromolecules, vol. 22, no. 2, Dec. 2020, pp. 681-689. https://doi.org/10.1021/acs.biomac.0c01504.