Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs)
Publication type: Journal Article
Publication date: 2018-05-04
scimago Q1
wos Q1
SJR: 1.142
CiteScore: 9.2
Impact factor: 5.4
ISSN: 15257797, 15264602
PubMed ID:
29727572
Materials Chemistry
Polymers and Plastics
Bioengineering
Biomaterials
Abstract
Safe and effective DNA delivery systems are required to enable or enhance clinical strategies and research involving gene therapy and DNA vaccinations. To address this delivery problem, a series of charge-altering releasable transporters (CARTs) with varied lipid content were prepared and evaluated for plasmid DNA (pDNA) delivery into cultured cells. These lipid-modified CART co-oligomers were synthesized in only two steps via sequential organocatalytic ring-opening polymerization of lipid-containing cyclic carbonate monomers and morpholinone monomers. Lipid variations of the CARTs substantially impacted the delivery efficiency of pDNA, with oleyl- and linoleyl-based CARTs showing enhanced performance relative to the commercial transfection agent Lipofectamine 2000 (L2000). The best-performing oleyl CART was carried forward to study stable luciferase transfection with a Sleeping Beauty ( SB) transposon system. The oleyl CART outperformed the L2000 positive control with respect to stable transfection efficiency. CART-pDNA complexes represent a new DNA delivery system for research and clinical applications.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
|
|
|
Journal of the American Chemical Society
4 publications, 11.43%
|
|
|
Biomacromolecules
3 publications, 8.57%
|
|
|
Chemical Science
2 publications, 5.71%
|
|
|
Proceedings of the National Academy of Sciences of the United States of America
2 publications, 5.71%
|
|
|
European Polymer Journal
1 publication, 2.86%
|
|
|
Blood advances
1 publication, 2.86%
|
|
|
Cancer Research
1 publication, 2.86%
|
|
|
Tissue Engineering and Regenerative Medicine
1 publication, 2.86%
|
|
|
Nature Chemistry
1 publication, 2.86%
|
|
|
Bioconjugate Chemistry
1 publication, 2.86%
|
|
|
Journal of Controlled Release
1 publication, 2.86%
|
|
|
Tetrahedron Letters
1 publication, 2.86%
|
|
|
Macromolecular Chemistry and Physics
1 publication, 2.86%
|
|
|
ChemPhysChem
1 publication, 2.86%
|
|
|
Advanced Functional Materials
1 publication, 2.86%
|
|
|
ACS Central Science
1 publication, 2.86%
|
|
|
Polymer Chemistry
1 publication, 2.86%
|
|
|
Green Chemistry
1 publication, 2.86%
|
|
|
Expert Opinion on Drug Delivery
1 publication, 2.86%
|
|
|
Pharmaceutics
1 publication, 2.86%
|
|
|
Nature Communications
1 publication, 2.86%
|
|
|
Mendeleev Communications
1 publication, 2.86%
|
|
|
Advanced healthcare materials
1 publication, 2.86%
|
|
|
Langmuir
1 publication, 2.86%
|
|
|
Polymer Science & Technology
1 publication, 2.86%
|
|
|
ACS Nano
1 publication, 2.86%
|
|
|
1
2
3
4
|
Publishers
|
2
4
6
8
10
12
|
|
|
American Chemical Society (ACS)
12 publications, 34.29%
|
|
|
Wiley
4 publications, 11.43%
|
|
|
Royal Society of Chemistry (RSC)
4 publications, 11.43%
|
|
|
Elsevier
3 publications, 8.57%
|
|
|
Springer Nature
3 publications, 8.57%
|
|
|
Cold Spring Harbor Laboratory
2 publications, 5.71%
|
|
|
Proceedings of the National Academy of Sciences (PNAS)
2 publications, 5.71%
|
|
|
American Society of Hematology
1 publication, 2.86%
|
|
|
American Association for Cancer Research (AACR)
1 publication, 2.86%
|
|
|
Taylor & Francis
1 publication, 2.86%
|
|
|
MDPI
1 publication, 2.86%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 publication, 2.86%
|
|
|
2
4
6
8
10
12
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
35
Total citations:
35
Citations from 2025:
5
(14.29%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Benner N. L. et al. Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs) // Biomacromolecules. 2018. Vol. 19. No. 7. pp. 2812-2824.
GOST all authors (up to 50)
Copy
Benner N. L., Near K. E., Bachmann M. H., Contag C. H., Waymouth R. M., WENDER P. H. Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs) // Biomacromolecules. 2018. Vol. 19. No. 7. pp. 2812-2824.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.biomac.8b00401
UR - https://doi.org/10.1021/acs.biomac.8b00401
TI - Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs)
T2 - Biomacromolecules
AU - Benner, Nancy L
AU - Near, Katherine E
AU - Bachmann, Michael H.
AU - Contag, Christopher H.
AU - Waymouth, Robert M.
AU - WENDER, PAUL H.
PY - 2018
DA - 2018/05/04
PB - American Chemical Society (ACS)
SP - 2812-2824
IS - 7
VL - 19
PMID - 29727572
SN - 1525-7797
SN - 1526-4602
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Benner,
author = {Nancy L Benner and Katherine E Near and Michael H. Bachmann and Christopher H. Contag and Robert M. Waymouth and PAUL H. WENDER},
title = {Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs)},
journal = {Biomacromolecules},
year = {2018},
volume = {19},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/acs.biomac.8b00401},
number = {7},
pages = {2812--2824},
doi = {10.1021/acs.biomac.8b00401}
}
Cite this
MLA
Copy
Benner, Nancy L., et al. “Functional DNA Delivery Enabled by Lipid-Modified Charge-Altering Releasable Transporters (CARTs).” Biomacromolecules, vol. 19, no. 7, May. 2018, pp. 2812-2824. https://doi.org/10.1021/acs.biomac.8b00401.