Polymorphism of Sildenafil: A New Metastable Desolvate
Publication type: Journal Article
Publication date: 2018-06-12
scimago Q2
wos Q1
SJR: 0.633
CiteScore: 5.6
Impact factor: 3.4
ISSN: 15287483, 15287505
General Chemistry
Condensed Matter Physics
General Materials Science
Abstract
A new anhydrous polymorph of the free base of sildenafil and two solvates (acetonitrile and propanenitrile) have been discovered and fully characterized. The new polymorph can be considered a desolvate of the acetonitrile solvate and is related to the most stable form I by morphotropism. The new polymorph can only be obtained by desolvation of the acetonitrile solvate. Thus, this study is a new example of the importance of this multicomponent family of solid forms in the discovery of new polymorphs of active pharmaceutical ingredients.
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Total citations:
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Citations from 2024:
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(27%)
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MLA
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GOST
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Barbas R., Font-Bardia M., Prohens R. Polymorphism of Sildenafil: A New Metastable Desolvate // Crystal Growth and Design. 2018. Vol. 18. No. 7. pp. 3740-3746.
GOST all authors (up to 50)
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Barbas R., Font-Bardia M., Prohens R. Polymorphism of Sildenafil: A New Metastable Desolvate // Crystal Growth and Design. 2018. Vol. 18. No. 7. pp. 3740-3746.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.cgd.8b00683
UR - https://doi.org/10.1021/acs.cgd.8b00683
TI - Polymorphism of Sildenafil: A New Metastable Desolvate
T2 - Crystal Growth and Design
AU - Barbas, Rafael
AU - Font-Bardia, M.
AU - Prohens, Rafel
PY - 2018
DA - 2018/06/12
PB - American Chemical Society (ACS)
SP - 3740-3746
IS - 7
VL - 18
SN - 1528-7483
SN - 1528-7505
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Barbas,
author = {Rafael Barbas and M. Font-Bardia and Rafel Prohens},
title = {Polymorphism of Sildenafil: A New Metastable Desolvate},
journal = {Crystal Growth and Design},
year = {2018},
volume = {18},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021/acs.cgd.8b00683},
number = {7},
pages = {3740--3746},
doi = {10.1021/acs.cgd.8b00683}
}
Cite this
MLA
Copy
Barbas, Rafael, et al. “Polymorphism of Sildenafil: A New Metastable Desolvate.” Crystal Growth and Design, vol. 18, no. 7, Jun. 2018, pp. 3740-3746. https://doi.org/10.1021/acs.cgd.8b00683.
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