Chemical Reviews, volume 121, issue 12, pages 6915-6990
Photoclick Chemistry: A Bright Idea.
Benjamin Fairbanks
1
,
Laura K Macdougall
1
,
Sudheendran Mavila
1
,
Jasmine Sinha
1
,
Bruce E Kirkpatrick
1, 2, 3
,
Kristi S. Anseth
1, 2
,
C. Bowman
1, 4
1
Department of Chemical and Biological Engineering, University of Colorado, Boulder, Colorado 80303, United States
|
2
The BioFrontiers Institute, University of Colorado, Boulder, Colorado 80303, United States
|
3
Medical Scientist Training Program, School of Medicine, University of Colorado, Aurora, Coorado 80045, United States
|
4
Materials Science and Engineering Program, University of Colorado, Boulder, Colorado 80303, United States
|
Publication type: Journal Article
Publication date: 2021-04-09
Journal:
Chemical Reviews
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 62.1
ISSN: 00092665, 15206890
General Chemistry
Abstract
At its basic conceptualization, photoclick chemistry embodies a collection of click reactions that are performed via the application of light. The emergence of this concept has had diverse impact over a broad range of chemical and biological research due to the spatiotemporal control, high selectivity, and excellent product yields afforded by the combination of light and click chemistry. While the reactions designated as "photoclick" have many important features in common, each has its own particular combination of advantages and shortcomings. A more extensive realization of the potential of this chemistry requires a broader understanding of the physical and chemical characteristics of the specific reactions. This review discusses the features of the most frequently employed photoclick reactions reported in the literature: photomediated azide-alkyne cycloadditions, other 1,3-dipolarcycloadditions, Diels-Alder and inverse electron demand Diels-Alder additions, radical alternating addition chain transfer additions, and nucleophilic additions. Applications of these reactions in a variety of chemical syntheses, materials chemistry, and biological contexts are surveyed, with particular attention paid to the respective strengths and limitations of each reaction and how that reaction benefits from its combination with light. Finally, challenges to broader employment of these reactions are discussed, along with strategies and opportunities to mitigate such obstacles.
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- We do not take into account publications without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Fairbanks B. et al. Photoclick Chemistry: A Bright Idea. // Chemical Reviews. 2021. Vol. 121. No. 12. pp. 6915-6990.
GOST all authors (up to 50)
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Fairbanks B., Macdougall L. K., Mavila S., Sinha J., Kirkpatrick B. E., Anseth K. S., Bowman C. Photoclick Chemistry: A Bright Idea. // Chemical Reviews. 2021. Vol. 121. No. 12. pp. 6915-6990.
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TY - JOUR
DO - 10.1021/acs.chemrev.0c01212
UR - https://doi.org/10.1021/acs.chemrev.0c01212
TI - Photoclick Chemistry: A Bright Idea.
T2 - Chemical Reviews
AU - Kirkpatrick, Bruce E
AU - Anseth, Kristi S.
AU - Bowman, C.
AU - Fairbanks, Benjamin
AU - Macdougall, Laura K
AU - Mavila, Sudheendran
AU - Sinha, Jasmine
PY - 2021
DA - 2021/04/09 00:00:00
PB - American Chemical Society (ACS)
SP - 6915-6990
IS - 12
VL - 121
SN - 0009-2665
SN - 1520-6890
ER -
Cite this
BibTex
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@article{2021_Fairbanks,
author = {Bruce E Kirkpatrick and Kristi S. Anseth and C. Bowman and Benjamin Fairbanks and Laura K Macdougall and Sudheendran Mavila and Jasmine Sinha},
title = {Photoclick Chemistry: A Bright Idea.},
journal = {Chemical Reviews},
year = {2021},
volume = {121},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021/acs.chemrev.0c01212},
number = {12},
pages = {6915--6990},
doi = {10.1021/acs.chemrev.0c01212}
}
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MLA
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Fairbanks, Benjamin, et al. “Photoclick Chemistry: A Bright Idea..” Chemical Reviews, vol. 121, no. 12, Apr. 2021, pp. 6915-6990. https://doi.org/10.1021/acs.chemrev.0c01212.