Chemical Reviews, volume 122, issue 4, pages 4636-4699

Large-Area Interfaces for Single-Molecule Label-free Bioelectronic Detection

Eleonora Macchia ¹

Fabrizio Torricelli ²

Paolo Bollella ^{3, 4}

Lucia Sarcina ³

Angelo Tricase ³

Cinzia Di Franco ⁵

Ronald Osterbacka ¹

Zsolt Miklós Kovacs‐Vajna ²

Gaetano Scamarcio ^{5, 6}

L. Torsi ^{1, 3, 4}

Hide authors affiliations Show authors affiliations: 6 affiliations

Faculty of Science and Engineering, Åbo Akademi University, 20500 Turku, Finland |

Dipartimento Ingegneria dell’Informazione, Università degli Studi di Brescia, 25123 Brescia, Italy |

Dipartimento di Chimica, Università degli Studi di Bari “Aldo Moro”, 70125 Bari, Italy |

⁴

Centre for Colloid and Surface Science - Università degli Studi di Bari “Aldo Moro”, 70125 Bari, Italy |

⁵

CNR, Istituto di Fotonica e Nanotecnologie, Sede di Bari, 70125 Bari, Italy |

⁶

Dipartimento Interateneo di Fisica “M. Merlin”, Università degli Studi di Bari “Aldo Moro”, 70125 Bari, Italy |

Publication type: Journal Article

Publication date: 2022-01-25

American Chemical Society (ACS)

Journal: Chemical Reviews

Quartile SCImago

Quartile WOS

Impact factor: 62.1

ISSN: 00092665, 15206890

DOI: 10.1021/acs.chemrev.1c00290

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General Chemistry

Abstract

Bioelectronic transducing surfaces that are nanometric in size have been the main route to detect single molecules. Though enabling the study of rarer events, such methodologies are not suited to assay at concentrations below the nanomolar level. Bioelectronic field-effect-transistors with a wide (μm2-mm2) transducing interface are also assumed to be not suited, because the molecule to be detected is orders of magnitude smaller than the transducing surface. Indeed, it is like seeing changes on the surface of a one-kilometer-wide pond when a droplet of water falls on it. However, it is a fact that a number of large-area transistors have been shown to detect at a limit of detection lower than femtomolar; they are also fast and hence innately suitable for point-of-care applications. This review critically discusses key elements, such as sensing materials, FET-structures, and target molecules that can be selectively assayed. The amplification effects enabling extremely sensitive large-area bioelectronic sensing are also addressed.

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Wiley	Wiley, 13, 24.53% Wiley 13 publications, 24.53%
American Chemical Society (ACS)	American Chemical Society (ACS), 11, 20.75% American Chemical Society (ACS) 11 publications, 20.75%
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IEEE	IEEE, 2, 3.77% IEEE 2 publications, 3.77%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 1, 1.89% American Association for the Advancement of Science (AAAS) 1 publication, 1.89%
IOP Publishing	IOP Publishing, 1, 1.89% IOP Publishing 1 publication, 1.89%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 1, 1.89% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 1 publication, 1.89%
	2 4 6 8 10 12 14

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Macchia E. et al. Large-Area Interfaces for Single-Molecule Label-free Bioelectronic Detection // Chemical Reviews. 2022. Vol. 122. No. 4. pp. 4636-4699.

GOST all authors (up to 50) Copy

Macchia E., Torricelli F., Bollella P., Sarcina L., Tricase A., Di Franco C., Osterbacka R., Kovacs‐Vajna Z. M., Scamarcio G., Torsi L. Large-Area Interfaces for Single-Molecule Label-free Bioelectronic Detection // Chemical Reviews. 2022. Vol. 122. No. 4. pp. 4636-4699.

RIS |

Cite this

RIS Copy

TY - JOUR

DO - 10.1021/acs.chemrev.1c00290

UR - https://doi.org/10.1021/acs.chemrev.1c00290

TI - Large-Area Interfaces for Single-Molecule Label-free Bioelectronic Detection

T2 - Chemical Reviews

AU - Bollella, Paolo

AU - Tricase, Angelo

AU - Di Franco, Cinzia

AU - Macchia, Eleonora

AU - Torsi, L.

AU - Torricelli, Fabrizio

AU - Sarcina, Lucia

AU - Osterbacka, Ronald

AU - Kovacs‐Vajna, Zsolt Miklós

AU - Scamarcio, Gaetano

PY - 2022

DA - 2022/01/25 00:00:00

PB - American Chemical Society (ACS)

SP - 4636-4699

IS - 4

VL - 122

SN - 0009-2665

SN - 1520-6890

ER -

BibTex |

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BibTex Copy

@article{2022_Macchia,

author = {Paolo Bollella and Angelo Tricase and Cinzia Di Franco and Eleonora Macchia and L. Torsi and Fabrizio Torricelli and Lucia Sarcina and Ronald Osterbacka and Zsolt Miklós Kovacs‐Vajna and Gaetano Scamarcio},

title = {Large-Area Interfaces for Single-Molecule Label-free Bioelectronic Detection},

journal = {Chemical Reviews},

year = {2022},

volume = {122},

publisher = {American Chemical Society (ACS)},

month = {jan},

url = {https://doi.org/10.1021/acs.chemrev.1c00290},

number = {4},

pages = {4636--4699},

doi = {10.1021/acs.chemrev.1c00290}

}

MLA

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MLA Copy

Macchia, Eleonora, et al. “Large-Area Interfaces for Single-Molecule Label-free Bioelectronic Detection.” Chemical Reviews, vol. 122, no. 4, Jan. 2022, pp. 4636-4699. https://doi.org/10.1021/acs.chemrev.1c00290.

Found error?

Publisher

American Chemical Society (ACS)

Journal

Chemical Reviews

Quartile SCImago

Quartile WOS

Impact factor

62.1

ISSN

00092665 (Print)
15206890 (Electronic)