Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
Publication type: Journal Article
Publication date: 2021-09-28
scimago Q1
wos Q1
SJR: 16.455
CiteScore: 100.5
Impact factor: 55.8
ISSN: 00092665, 15206890
PubMed ID:
34582186
General Chemistry
Abstract
This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the use of light combined with a light-activated chemical, referred to as a PS. Attractively, PDT is one of the alternatives to conventional cancer treatment due to its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although the concept of photosensitizer-based photodynamic therapy has been widely adopted for clinical trials and bioimaging, until now, to our surprise, there has been no relevant review article on rational designs of organic PSs for PDT. Furthermore, most of published review articles in PDT focused on nanomaterials and nanotechnology based on traditional PSs. Therefore, this review aimed at reporting recent strategies to develop innovative organic photosensitizers for enhanced photodynamic therapy, with each example described in detail instead of providing only a general overview, as is typically done in previous reviews of PDT, to provide intuitive, vivid, and specific insights to the readers.
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1.5k
Total citations:
1468
Citations from 2025:
492
(33.58%)
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GOST
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Pham T. C. et al. Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy // Chemical Reviews. 2021. Vol. 121. No. 21. pp. 13454-13619.
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Pham T. C., Nguyen V. N., Choi Y., Lee S., Yoon J. Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy // Chemical Reviews. 2021. Vol. 121. No. 21. pp. 13454-13619.
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TY - JOUR
DO - 10.1021/acs.chemrev.1c00381
UR - https://doi.org/10.1021/acs.chemrev.1c00381
TI - Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy
T2 - Chemical Reviews
AU - Pham, Thanh Chung
AU - Nguyen, Van Nghia
AU - Choi, Yeonghwan
AU - Lee, Songyi
AU - Yoon, Juyoung
PY - 2021
DA - 2021/09/28
PB - American Chemical Society (ACS)
SP - 13454-13619
IS - 21
VL - 121
PMID - 34582186
SN - 0009-2665
SN - 1520-6890
ER -
Cite this
BibTex (up to 50 authors)
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@article{2021_Pham,
author = {Thanh Chung Pham and Van Nghia Nguyen and Yeonghwan Choi and Songyi Lee and Juyoung Yoon},
title = {Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy},
journal = {Chemical Reviews},
year = {2021},
volume = {121},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/acs.chemrev.1c00381},
number = {21},
pages = {13454--13619},
doi = {10.1021/acs.chemrev.1c00381}
}
Cite this
MLA
Copy
Pham, Thanh Chung, et al. “Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy.” Chemical Reviews, vol. 121, no. 21, Sep. 2021, pp. 13454-13619. https://doi.org/10.1021/acs.chemrev.1c00381.