Chemical Reviews, volume 116, issue 2, pages 422-518

Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas.

Yu Zhou ¹

Jiang Wang ¹

Zhanni Gu ¹

Shuni Wang ¹

Wei Zhu ¹

José Luis Aceña ^{2, 3}

Vadim A Soloshonok ^{2, 4}

Kunisuke Izawa ⁵

Hong Liu ¹

Hide authors affiliations Show authors affiliations: 5 affiliations

Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China |

Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018 San Sebastián, Spain |

Department of Organic Chemistry, Autónoma University of Madrid, Cantoblanco, 28049 Madrid, Spain |

⁴

IKERBASQUE, Basque Foundation for Science, María Díaz de Haro 3, 48013 Bilbao, Spain |

⁵

Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka, Japan 533-0024 |

Publication type: Journal Article

Publication date: 2016-01-12

American Chemical Society (ACS)

Journal: Chemical Reviews

Quartile SCImago

Quartile WOS

Impact factor: 62.1

ISSN: 00092665, 15206890

DOI: 10.1021/acs.chemrev.5b00392

Copy DOI

General Chemistry

Abstract

Compounds Currently in Phase II−III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas Yu Zhou,† Jiang Wang,† Zhanni Gu,† Shuni Wang,† Wei Zhu,† Jose ́ Luis Aceña,*,‡,§ Vadim A. Soloshonok,*,‡,∥ Kunisuke Izawa,* and Hong Liu*,† †Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China ‡Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizab́al 3, 20018 San Sebastiań, Spain Department of Organic Chemistry, Autońoma University of Madrid, Cantoblanco, 28049 Madrid, Spain IKERBASQUE, Basque Foundation for Science, María Díaz de Haro 3, 48013 Bilbao, Spain Hamari Chemicals Ltd., 1-4-29 Kunijima, Higashi-Yodogawa-ku, Osaka, Japan 533-0024

By date By citations

Top-30

Citations by journals

	20 40 60 80 100 120 140 160 180
Journal of Organic Chemistry	Journal of Organic Chemistry, 169, 7.9% Journal of Organic Chemistry 169 publications, 7.9%
Organic Letters	Organic Letters, 169, 7.9% Organic Letters 169 publications, 7.9%
Angewandte Chemie - International Edition	Angewandte Chemie - International Edition, 107, 5% Angewandte Chemie - International Edition 107 publications, 5%
Angewandte Chemie	Angewandte Chemie, 107, 5% Angewandte Chemie 107 publications, 5%
Organic and Biomolecular Chemistry	Organic and Biomolecular Chemistry, 93, 4.35% Organic and Biomolecular Chemistry 93 publications, 4.35%
European Journal of Organic Chemistry	European Journal of Organic Chemistry, 91, 4.25% European Journal of Organic Chemistry 91 publications, 4.25%
Advanced Synthesis and Catalysis	Advanced Synthesis and Catalysis, 91, 4.25% Advanced Synthesis and Catalysis 91 publications, 4.25%
Journal of Fluorine Chemistry	Journal of Fluorine Chemistry, 87, 4.07% Journal of Fluorine Chemistry 87 publications, 4.07%
Chemistry - A European Journal	Chemistry - A European Journal, 82, 3.83% Chemistry - A European Journal 82 publications, 3.83%
Chemical Communications	Chemical Communications, 81, 3.79% Chemical Communications 81 publications, 3.79%
Organic Chemistry Frontiers	Organic Chemistry Frontiers, 77, 3.6% Organic Chemistry Frontiers 77 publications, 3.6%
ACS Catalysis	ACS Catalysis, 42, 1.96% ACS Catalysis 42 publications, 1.96%
Journal of the American Chemical Society	Journal of the American Chemical Society, 42, 1.96% Journal of the American Chemical Society 42 publications, 1.96%
Molecules	Molecules, 39, 1.82% Molecules 39 publications, 1.82%
Asian Journal of Organic Chemistry	Asian Journal of Organic Chemistry, 36, 1.68% Asian Journal of Organic Chemistry 36 publications, 1.68%
Tetrahedron Letters	Tetrahedron Letters, 35, 1.64% Tetrahedron Letters 35 publications, 1.64%
Beilstein Journal of Organic Chemistry	Beilstein Journal of Organic Chemistry, 31, 1.45% Beilstein Journal of Organic Chemistry 31 publications, 1.45%
Chemical Science	Chemical Science, 31, 1.45% Chemical Science 31 publications, 1.45%
Synthesis	Synthesis, 31, 1.45% Synthesis 31 publications, 1.45%
Tetrahedron	Tetrahedron, 26, 1.21% Tetrahedron 26 publications, 1.21%
Chemical Record	Chemical Record, 21, 0.98% Chemical Record 21 publications, 0.98%
ChemistrySelect	ChemistrySelect, 21, 0.98% ChemistrySelect 21 publications, 0.98%
RSC Advances	RSC Advances, 21, 0.98% RSC Advances 21 publications, 0.98%
Green Chemistry	Green Chemistry, 18, 0.84% Green Chemistry 18 publications, 0.84%
Chinese Chemical Letters	Chinese Chemical Letters, 17, 0.79% Chinese Chemical Letters 17 publications, 0.79%
Organic Process Research and Development	Organic Process Research and Development, 16, 0.75% Organic Process Research and Development 16 publications, 0.75%
Journal of Medicinal Chemistry	Journal of Medicinal Chemistry, 16, 0.75% Journal of Medicinal Chemistry 16 publications, 0.75%
Chinese Journal of Chemistry	Chinese Journal of Chemistry, 15, 0.7% Chinese Journal of Chemistry 15 publications, 0.7%
Synlett	Synlett, 14, 0.65% Synlett 14 publications, 0.65%
	20 40 60 80 100 120 140 160 180

Citations by publishers

	100 200 300 400 500 600 700
Wiley	Wiley, 657, 30.7% Wiley 657 publications, 30.7%
American Chemical Society (ACS)	American Chemical Society (ACS), 530, 24.77% American Chemical Society (ACS) 530 publications, 24.77%
Royal Society of Chemistry (RSC)	Royal Society of Chemistry (RSC), 371, 17.34% Royal Society of Chemistry (RSC) 371 publications, 17.34%
Elsevier	Elsevier, 279, 13.04% Elsevier 279 publications, 13.04%
Springer Nature	Springer Nature, 68, 3.18% Springer Nature 68 publications, 3.18%
Multidisciplinary Digital Publishing Institute (MDPI)	Multidisciplinary Digital Publishing Institute (MDPI), 61, 2.85% Multidisciplinary Digital Publishing Institute (MDPI) 61 publications, 2.85%
Thieme	Thieme, 45, 2.1% Thieme 45 publications, 2.1%
Beilstein-Institut	Beilstein-Institut, 31, 1.45% Beilstein-Institut 31 publications, 1.45%
Taylor & Francis	Taylor & Francis, 15, 0.7% Taylor & Francis 15 publications, 0.7%
Pleiades Publishing	Pleiades Publishing, 14, 0.65% Pleiades Publishing 14 publications, 0.65%
Bentham Science	Bentham Science, 8, 0.37% Bentham Science 8 publications, 0.37%
Shanghai Institute of Organic Chemistry	Shanghai Institute of Organic Chemistry, 8, 0.37% Shanghai Institute of Organic Chemistry 8 publications, 0.37%
The Chemical Society of Japan	The Chemical Society of Japan, 7, 0.33% The Chemical Society of Japan 7 publications, 0.33%
Frontiers Media S.A.	Frontiers Media S.A., 5, 0.23% Frontiers Media S.A. 5 publications, 0.23%
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii	Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii, 3, 0.14% Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii 3 publications, 0.14%
American Association for the Advancement of Science (AAAS)	American Association for the Advancement of Science (AAAS), 3, 0.14% American Association for the Advancement of Science (AAAS) 3 publications, 0.14%
Canadian Science Publishing	Canadian Science Publishing, 2, 0.09% Canadian Science Publishing 2 publications, 0.09%
Pharmaceutical Society of Japan	Pharmaceutical Society of Japan, 2, 0.09% Pharmaceutical Society of Japan 2 publications, 0.09%
Society of Synthetic Organic Chemistry	Society of Synthetic Organic Chemistry, 2, 0.09% Society of Synthetic Organic Chemistry 2 publications, 0.09%
Akademiai Kiado	Akademiai Kiado, 2, 0.09% Akademiai Kiado 2 publications, 0.09%
King Saud University	King Saud University, 2, 0.09% King Saud University 2 publications, 0.09%
Scientific Research Publishing	Scientific Research Publishing, 2, 0.09% Scientific Research Publishing 2 publications, 0.09%
American Society for Pharmacology and Experimental Therapeutics	American Society for Pharmacology and Experimental Therapeutics, 1, 0.05% American Society for Pharmacology and Experimental Therapeutics 1 publication, 0.05%
CSIRO Publishing	CSIRO Publishing, 1, 0.05% CSIRO Publishing 1 publication, 0.05%
The Electrochemical Society of Japan	The Electrochemical Society of Japan, 1, 0.05% The Electrochemical Society of Japan 1 publication, 0.05%
Impact Journals	Impact Journals, 1, 0.05% Impact Journals 1 publication, 0.05%
International Union of Crystallography (IUCr)	International Union of Crystallography (IUCr), 1, 0.05% International Union of Crystallography (IUCr) 1 publication, 0.05%
Akademizdatcenter Nauka	Akademizdatcenter Nauka, 1, 0.05% Akademizdatcenter Nauka 1 publication, 0.05%
Public Library of Science (PLoS)	Public Library of Science (PLoS), 1, 0.05% Public Library of Science (PLoS) 1 publication, 0.05%
	100 200 300 400 500 600 700

We do not take into account publications without a DOI.
Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
Statistics recalculated weekly.

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Zhou Yu. et al. Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas. // Chemical Reviews. 2016. Vol. 116. No. 2. pp. 422-518.

GOST all authors (up to 50) Copy

Zhou Yu., Wang J., Gu Z., Wang S., Zhu W., Aceña J. L., Soloshonok V. A., Izawa K., Liu H. Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas. // Chemical Reviews. 2016. Vol. 116. No. 2. pp. 422-518.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/acs.chemrev.5b00392

UR - https://doi.org/10.1021/acs.chemrev.5b00392

TI - Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas.

T2 - Chemical Reviews

AU - Gu, Zhanni

AU - Wang, Shuni

AU - Aceña, José Luis

AU - Soloshonok, Vadim A

AU - Zhou, Yu

AU - Wang, Jiang

AU - Zhu, Wei

AU - Izawa, Kunisuke

AU - Liu, Hong

PY - 2016

DA - 2016/01/12 00:00:00

PB - American Chemical Society (ACS)

SP - 422-518

IS - 2

VL - 116

SN - 0009-2665

SN - 1520-6890

ER -

BibTex |

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BibTex Copy

@article{2016_Zhou,

author = {Zhanni Gu and Shuni Wang and José Luis Aceña and Vadim A Soloshonok and Yu Zhou and Jiang Wang and Wei Zhu and Kunisuke Izawa and Hong Liu},

title = {Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas.},

journal = {Chemical Reviews},

year = {2016},

volume = {116},

publisher = {American Chemical Society (ACS)},

month = {jan},

url = {https://doi.org/10.1021/acs.chemrev.5b00392},

number = {2},

pages = {422--518},

doi = {10.1021/acs.chemrev.5b00392}

}

MLA

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MLA Copy

Zhou, Yu., et al. “Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas..” Chemical Reviews, vol. 116, no. 2, Jan. 2016, pp. 422-518. https://doi.org/10.1021/acs.chemrev.5b00392.

Found error?

Publisher

American Chemical Society (ACS)

Journal

Chemical Reviews

Quartile SCImago

Quartile WOS

Impact factor

62.1

ISSN

00092665 (Print)
15206890 (Electronic)