Chemical Reviews, volume 118, issue 14, pages 6844-6892

Block Copolymer Micelles in Nanomedicine Applications

1
 
Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, 3-25-14, Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan
2
 
Policy Alternatives Research Institute, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Publication typeJournal Article
Publication date2018-06-29
Journal: Chemical Reviews
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor62.1
ISSN00092665, 15206890
General Chemistry
Abstract
Polymeric micelles are demonstrating high potential as nanomedicines capable of controlling the distribution and function of loaded bioactive agents in the body, effectively overcoming biological barriers, and various formulations are engaged in intensive preclinical and clinical testing. This Review focuses on polymeric micelles assembled through multimolecular interactions between block copolymers and the loaded drugs, proteins, or nucleic acids as translationable nanomedicines. The aspects involved in the design of successful micellar carriers are described in detail on the basis of the type of polymer/payload interaction, as well as the interplay of micelles with the biological interface, emphasizing on the chemistry and engineering of the block copolymers. By shaping these features, polymeric micelles have been propitious for delivering a wide range of therapeutics through effective sensing of targets in the body and adjustment of their properties in response to particular stimuli, modulating the activity of the loaded drugs at the targeted sites, even at the subcellular level. Finally, the future perspectives and imminent challenges for polymeric micelles as nanomedicines are discussed, anticipating to spur further innovations.

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Cabral H. et al. Block Copolymer Micelles in Nanomedicine Applications // Chemical Reviews. 2018. Vol. 118. No. 14. pp. 6844-6892.
GOST all authors (up to 50) Copy
Cabral H., Miyata K., Osada K., Kataoka K. Block Copolymer Micelles in Nanomedicine Applications // Chemical Reviews. 2018. Vol. 118. No. 14. pp. 6844-6892.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1021/acs.chemrev.8b00199
UR - https://doi.org/10.1021%2Facs.chemrev.8b00199
TI - Block Copolymer Micelles in Nanomedicine Applications
T2 - Chemical Reviews
AU - Cabral, Horacio
AU - Miyata, Kanjiro
AU - Osada, Kensuke
AU - Kataoka, Kazunori
PY - 2018
DA - 2018/06/29 00:00:00
PB - American Chemical Society (ACS)
SP - 6844-6892
IS - 14
VL - 118
SN - 0009-2665
SN - 1520-6890
ER -
BibTex |
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BibTex Copy
@article{2018_Cabral
author = {Horacio Cabral and Kanjiro Miyata and Kensuke Osada and Kazunori Kataoka},
title = {Block Copolymer Micelles in Nanomedicine Applications},
journal = {Chemical Reviews},
year = {2018},
volume = {118},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021%2Facs.chemrev.8b00199},
number = {14},
pages = {6844--6892},
doi = {10.1021/acs.chemrev.8b00199}
}
MLA
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MLA Copy
Cabral, Horacio, et al. “Block Copolymer Micelles in Nanomedicine Applications.” Chemical Reviews, vol. 118, no. 14, Jun. 2018, pp. 6844-6892. https://doi.org/10.1021%2Facs.chemrev.8b00199.
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