A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin–Thioredoxin Reductase System Activity by Induced Oxidization of the Protein
Publication type: Journal Article
Publication date: 2018-04-24
scimago Q1
wos Q1
SJR: 0.958
CiteScore: 7.4
Impact factor: 4.7
ISSN: 00201669, 1520510X
PubMed ID:
29688719
Inorganic Chemistry
Physical and Theoretical Chemistry
Abstract
Thioredoxin (Trx) is an important enzyme in the redox signaling pathway and is usually overexpressed in tumor cells. We demonstrate herein that the photoactive platinum(IV) anticancer complex trans,trans,trans-[Pt(N3)2(OH)2(Py)2] (1) can bind to His, Glu, and Gln residues of Trx upon the irradiation of blue light. More importantly, complex 1 can also induce the oxidation of Met, Trp, and the Cys catalytic sites to form disulfide bonds by generating reactive oxygen species (ROS) upon photoactivation. These eventually lead to inhibition of activity of Trx enzyme and the Trx system and further increase in the cellular ROS level. We speculate that the oxidative damage not only inhibits Trx activity but also greatly contributes to the anticancer action of complex 1.
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Total citations:
29
Citations from 2025:
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(10.34%)
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GOST
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Du J. et al. A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin–Thioredoxin Reductase System Activity by Induced Oxidization of the Protein // Inorganic Chemistry. 2018. Vol. 57. No. 9. pp. 5575-5584.
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Du J., WEI Y., Zhao Y., Xu F., Wang Y., Zheng W., Luo Q., Wang M., Wang F. A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin–Thioredoxin Reductase System Activity by Induced Oxidization of the Protein // Inorganic Chemistry. 2018. Vol. 57. No. 9. pp. 5575-5584.
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RIS
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TY - JOUR
DO - 10.1021/acs.inorgchem.8b00529
UR - https://doi.org/10.1021/acs.inorgchem.8b00529
TI - A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin–Thioredoxin Reductase System Activity by Induced Oxidization of the Protein
T2 - Inorganic Chemistry
AU - Du, Jun
AU - WEI, YUANYUAN
AU - Zhao, Yao
AU - Xu, Fengmin
AU - Wang, Yuanyuan
AU - Zheng, Wei
AU - Luo, Qun
AU - Wang, Ming
AU - Wang, Fuyi
PY - 2018
DA - 2018/04/24
PB - American Chemical Society (ACS)
SP - 5575-5584
IS - 9
VL - 57
PMID - 29688719
SN - 0020-1669
SN - 1520-510X
ER -
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@article{2018_Du,
author = {Jun Du and YUANYUAN WEI and Yao Zhao and Fengmin Xu and Yuanyuan Wang and Wei Zheng and Qun Luo and Ming Wang and Fuyi Wang},
title = {A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin–Thioredoxin Reductase System Activity by Induced Oxidization of the Protein},
journal = {Inorganic Chemistry},
year = {2018},
volume = {57},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021/acs.inorgchem.8b00529},
number = {9},
pages = {5575--5584},
doi = {10.1021/acs.inorgchem.8b00529}
}
Cite this
MLA
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Du, Jun, et al. “A Photoactive Platinum(IV) Anticancer Complex Inhibits Thioredoxin–Thioredoxin Reductase System Activity by Induced Oxidization of the Protein.” Inorganic Chemistry, vol. 57, no. 9, Apr. 2018, pp. 5575-5584. https://doi.org/10.1021/acs.inorgchem.8b00529.