Defending Antiviral Cationic Amphiphilic Drugs That May Cause Drug-Induced Phospholipidosis
T.M. Lane
1
,
1
Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, North Carolina 27606, United States
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Publication type: Journal Article
Publication date: 2021-09-13
scimago Q1
wos Q1
SJR: 1.467
CiteScore: 9.8
Impact factor: 5.3
ISSN: 15499596, 1549960X
PubMed ID:
34516123
General Chemistry
Computer Science Applications
General Chemical Engineering
Library and Information Sciences
Abstract
A recent publication in Science has proposed that cationic amphiphilic drugs repurposed for COVID-19 typically use phosholipidosis as their antiviral mechanism of action in cells but will have no in vivo efficacy. On the contrary, our viewpoint, supported by additional experimental data for similar cationic amphiphilic drugs, indicates that many of these molecules have both in vitro and in vivo efficacy with no reported phospholipidosis, and therefore, this class of compounds should not be avoided but further explored, as we continue the search for broad spectrum antivirals.
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13
Total citations:
13
Citations from 2024:
0
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GOST
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Lane T., Ekins S. Defending Antiviral Cationic Amphiphilic Drugs That May Cause Drug-Induced Phospholipidosis // Journal of Chemical Information and Modeling. 2021. Vol. 61. No. 9. pp. 4125-4130.
GOST all authors (up to 50)
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Lane T., Ekins S. Defending Antiviral Cationic Amphiphilic Drugs That May Cause Drug-Induced Phospholipidosis // Journal of Chemical Information and Modeling. 2021. Vol. 61. No. 9. pp. 4125-4130.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.jcim.1c00903
UR - https://doi.org/10.1021/acs.jcim.1c00903
TI - Defending Antiviral Cationic Amphiphilic Drugs That May Cause Drug-Induced Phospholipidosis
T2 - Journal of Chemical Information and Modeling
AU - Lane, T.M.
AU - Ekins, Sean
PY - 2021
DA - 2021/09/13
PB - American Chemical Society (ACS)
SP - 4125-4130
IS - 9
VL - 61
PMID - 34516123
SN - 1549-9596
SN - 1549-960X
ER -
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BibTex (up to 50 authors)
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@article{2021_Lane,
author = {T.M. Lane and Sean Ekins},
title = {Defending Antiviral Cationic Amphiphilic Drugs That May Cause Drug-Induced Phospholipidosis},
journal = {Journal of Chemical Information and Modeling},
year = {2021},
volume = {61},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/acs.jcim.1c00903},
number = {9},
pages = {4125--4130},
doi = {10.1021/acs.jcim.1c00903}
}
Cite this
MLA
Copy
Lane, T.M., and Sean Ekins. “Defending Antiviral Cationic Amphiphilic Drugs That May Cause Drug-Induced Phospholipidosis.” Journal of Chemical Information and Modeling, vol. 61, no. 9, Sep. 2021, pp. 4125-4130. https://doi.org/10.1021/acs.jcim.1c00903.
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