Journal of Medicinal Chemistry

, том 65 , издание 14 , страницы 9564-9579

Recent Advances with KDM4 Inhibitors and Potential Applications

Тип публикации: Journal Article

Дата публикации: 2022-07-15

American Chemical Society (ACS)

Journal of Medicinal Chemistry

scimago Q1

wos Q1

white level БС1

SJR: 1.801

CiteScore: 11.5

Impact factor: 6.8

ISSN: 00222623, 15204804

DOI: 10.1021/acs.jmedchem.2c00680

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PubMed ID: 35838529

Drug Discovery

Molecular Medicine

Краткое описание

The histone lysine demethylase 4 (KDM4) family plays an important role in regulating gene transcription, DNA repair, and metabolism. The dysregulation of KDM4 functions is associated with many human disorders, including cancer, obesity, and cardiovascular diseases. Selective and potent KDM4 inhibitors may help not only to understand the role of KDM4 in these disorders but also to provide potential therapeutic opportunities. Here, we provide an overview of the field and discuss current status, challenges, and opportunities lying ahead in the development of KDM4-based anticancer therapeutics.

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ГОСТ |

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Wu Q. et al. Recent Advances with KDM4 Inhibitors and Potential Applications // Journal of Medicinal Chemistry. 2022. Vol. 65. No. 14. pp. 9564-9579.

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Wu Q., Young B. M., Wang Y., Davidoff A. M., Rankovic Z., Yang J. Recent Advances with KDM4 Inhibitors and Potential Applications // Journal of Medicinal Chemistry. 2022. Vol. 65. No. 14. pp. 9564-9579.

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TY - JOUR

DO - 10.1021/acs.jmedchem.2c00680

UR - https://doi.org/10.1021/acs.jmedchem.2c00680

TI - Recent Advances with KDM4 Inhibitors and Potential Applications

T2 - Journal of Medicinal Chemistry

AU - Wu, Qiong

AU - Young, Brandon M.

AU - Wang, Yan

AU - Davidoff, Andrew M.

AU - Rankovic, Zoran

AU - Yang, Jun

PY - 2022

DA - 2022/07/15

PB - American Chemical Society (ACS)

SP - 9564-9579

IS - 14

VL - 65

PMID - 35838529

SN - 0022-2623

SN - 1520-4804

ER -

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@article{2022_Wu,

author = {Qiong Wu and Brandon M. Young and Yan Wang and Andrew M. Davidoff and Zoran Rankovic and Jun Yang},

title = {Recent Advances with KDM4 Inhibitors and Potential Applications},

journal = {Journal of Medicinal Chemistry},

year = {2022},

volume = {65},

publisher = {American Chemical Society (ACS)},

month = {jul},

url = {https://doi.org/10.1021/acs.jmedchem.2c00680},

number = {14},

pages = {9564--9579},

doi = {10.1021/acs.jmedchem.2c00680}

}

MLA

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Wu, Qiong, et al. “Recent Advances with KDM4 Inhibitors and Potential Applications.” Journal of Medicinal Chemistry, vol. 65, no. 14, Jul. 2022, pp. 9564-9579. https://doi.org/10.1021/acs.jmedchem.2c00680.