An Update on the Nitrogen Heterocycle Compositions and Properties of U.S. FDA-Approved Pharmaceuticals (2013–2023)
2
Discovery Research, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States
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Publication type: Journal Article
Publication date: 2024-07-12
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
38995264
Abstract
This Perspective is a continuation of our analysis of U.S. FDA-approved small-molecule drugs (1938–2012) containing nitrogen heterocycles. In this study we report drug structure and property analyses of 321 unique new small-molecule drugs approved from January 2013 to December 2023 as well as information about frequency of important heteroatoms such as sulfur and fluorine and key small nitrogen substituents (CN and NO2). The most notable change is an incredible increase in drugs containing at least one nitrogen heterocycle─82%, compared to 59% from preceding decades─as well as a significant increase in the number of nitrogen heterocycles per drug. Pyridine has claimed the #1 high-frequency nitrogen heterocycle occurrence spot from piperidine (#2), with pyrimidine (#5), pyrazole (#6), and morpholine (#9) being the big top 10 climbers. Also notable is high number of fused nitrogen heterocycles, apparently driven largely by newly approved cancer drugs.
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507
Total citations:
507
Citations from 2024:
489
(97.02%)
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Marshall C. M. et al. An Update on the Nitrogen Heterocycle Compositions and Properties of U.S. FDA-Approved Pharmaceuticals (2013–2023) // Journal of Medicinal Chemistry. 2024. Vol. 67. No. 14. pp. 11622-11655.
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Marshall C. M., Federice J. G., Bell C. N., Cox P. B., Njardarson J. T. An Update on the Nitrogen Heterocycle Compositions and Properties of U.S. FDA-Approved Pharmaceuticals (2013–2023) // Journal of Medicinal Chemistry. 2024. Vol. 67. No. 14. pp. 11622-11655.
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TY - JOUR
DO - 10.1021/acs.jmedchem.4c01122
UR - https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01122
TI - An Update on the Nitrogen Heterocycle Compositions and Properties of U.S. FDA-Approved Pharmaceuticals (2013–2023)
T2 - Journal of Medicinal Chemistry
AU - Marshall, Christopher M.
AU - Federice, John G.
AU - Bell, Chloe N.
AU - Cox, Philip B
AU - Njardarson, J. T.
PY - 2024
DA - 2024/07/12
PB - American Chemical Society (ACS)
SP - 11622-11655
IS - 14
VL - 67
PMID - 38995264
SN - 0022-2623
SN - 1520-4804
ER -
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@article{2024_Marshall,
author = {Christopher M. Marshall and John G. Federice and Chloe N. Bell and Philip B Cox and J. T. Njardarson},
title = {An Update on the Nitrogen Heterocycle Compositions and Properties of U.S. FDA-Approved Pharmaceuticals (2013–2023)},
journal = {Journal of Medicinal Chemistry},
year = {2024},
volume = {67},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01122},
number = {14},
pages = {11622--11655},
doi = {10.1021/acs.jmedchem.4c01122}
}
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MLA
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Marshall, Christopher M., et al. “An Update on the Nitrogen Heterocycle Compositions and Properties of U.S. FDA-Approved Pharmaceuticals (2013–2023).” Journal of Medicinal Chemistry, vol. 67, no. 14, Jul. 2024, pp. 11622-11655. https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c01122.
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