Applications of Fluorine in Medicinal Chemistry
Publication type: Journal Article
Publication date: 2015-07-22
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
26200936
Drug Discovery
Molecular Medicine
Abstract
The role of fluorine in drug design and development is expanding rapidly as we learn more about the unique properties associated with this unusual element and how to deploy it with greater sophistication. The judicious introduction of fluorine into a molecule can productively influence conformation, pKa, intrinsic potency, membrane permeability, metabolic pathways, and pharmacokinetic properties. In addition, (18)F has been established as a useful positron emitting isotope for use with in vivo imaging technology that potentially has extensive application in drug discovery and development, often limited only by convenient synthetic accessibility to labeled compounds. The wide ranging applications of fluorine in drug design are providing a strong stimulus for the development of new synthetic methodologies that allow more facile access to a wide range of fluorinated compounds. In this review, we provide an update on the effects of the strategic incorporation of fluorine in drug molecules and applications in positron emission tomography.
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Total citations:
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Citations from 2025:
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Cite this
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GOST
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Gillis E. P. et al. Applications of Fluorine in Medicinal Chemistry // Journal of Medicinal Chemistry. 2015. Vol. 58. No. 21. pp. 8315-8359.
GOST all authors (up to 50)
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Gillis E. P., Eastman K. J., Hill M. D., Donnelly D. J., Meanwell N. A. Applications of Fluorine in Medicinal Chemistry // Journal of Medicinal Chemistry. 2015. Vol. 58. No. 21. pp. 8315-8359.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.jmedchem.5b00258
UR - https://doi.org/10.1021/acs.jmedchem.5b00258
TI - Applications of Fluorine in Medicinal Chemistry
T2 - Journal of Medicinal Chemistry
AU - Gillis, Eric P
AU - Eastman, K. J.
AU - Hill, Matthew D
AU - Donnelly, David J.
AU - Meanwell, Nicholas A.
PY - 2015
DA - 2015/07/22
PB - American Chemical Society (ACS)
SP - 8315-8359
IS - 21
VL - 58
PMID - 26200936
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2015_Gillis,
author = {Eric P Gillis and K. J. Eastman and Matthew D Hill and David J. Donnelly and Nicholas A. Meanwell},
title = {Applications of Fluorine in Medicinal Chemistry},
journal = {Journal of Medicinal Chemistry},
year = {2015},
volume = {58},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021/acs.jmedchem.5b00258},
number = {21},
pages = {8315--8359},
doi = {10.1021/acs.jmedchem.5b00258}
}
Cite this
MLA
Copy
Gillis, Eric P., et al. “Applications of Fluorine in Medicinal Chemistry.” Journal of Medicinal Chemistry, vol. 58, no. 21, Jul. 2015, pp. 8315-8359. https://doi.org/10.1021/acs.jmedchem.5b00258.