A Survey of the Structures of US FDA Approved Combination Drugs
Тип публикации: Journal Article
Дата публикации: 2018-11-16
scimago Q1
wos Q1
БС1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
30444362
Drug Discovery
Molecular Medicine
Краткое описание
Combination drugs are an important class of US FDA approved pharmaceuticals. These drugs have been on a continuous growth trajectory since the first combination drugs were approved in the 1940s. In this Perspective, we report the first comprehensive compilation and analysis of US FDA approved combination drugs, from the first approval in 1943 through 2018. Our database contains 419 combination drugs, which are represented by 328 unique small molecule structures. Breakdown of these drugs according to disease category, structure, combination composition, and year of approval is presented as well as the top 24 most commonly used small molecule combination drug components. For frequently used small molecule components, we present "relationship diagrams" to aid in the visualization of the many drug combinations these structures are part of. The main body contains 10 disease-focused sections wherein every small molecule component utilized as part of a combination for each disease category is displayed.
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ГОСТ
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Das P. et al. A Survey of the Structures of US FDA Approved Combination Drugs // Journal of Medicinal Chemistry. 2018. Vol. 62. No. 9. pp. 4265-4311.
ГОСТ со всеми авторами (до 50)
Скопировать
Das P., Delost M. D., Qureshi M. H., Smith D. T., Njardarson J. T. A Survey of the Structures of US FDA Approved Combination Drugs // Journal of Medicinal Chemistry. 2018. Vol. 62. No. 9. pp. 4265-4311.
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RIS
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TY - JOUR
DO - 10.1021/acs.jmedchem.8b01610
UR - https://doi.org/10.1021/acs.jmedchem.8b01610
TI - A Survey of the Structures of US FDA Approved Combination Drugs
T2 - Journal of Medicinal Chemistry
AU - Das, Pradipta
AU - Delost, Michael D
AU - Qureshi, Munaum H
AU - Smith, David T
AU - Njardarson, J. T.
PY - 2018
DA - 2018/11/16
PB - American Chemical Society (ACS)
SP - 4265-4311
IS - 9
VL - 62
PMID - 30444362
SN - 0022-2623
SN - 1520-4804
ER -
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BibTex (до 50 авторов)
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@article{2018_Das,
author = {Pradipta Das and Michael D Delost and Munaum H Qureshi and David T Smith and J. T. Njardarson},
title = {A Survey of the Structures of US FDA Approved Combination Drugs},
journal = {Journal of Medicinal Chemistry},
year = {2018},
volume = {62},
publisher = {American Chemical Society (ACS)},
month = {nov},
url = {https://doi.org/10.1021/acs.jmedchem.8b01610},
number = {9},
pages = {4265--4311},
doi = {10.1021/acs.jmedchem.8b01610}
}
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MLA
Скопировать
Das, Pradipta, et al. “A Survey of the Structures of US FDA Approved Combination Drugs.” Journal of Medicinal Chemistry, vol. 62, no. 9, Nov. 2018, pp. 4265-4311. https://doi.org/10.1021/acs.jmedchem.8b01610.