Precision Cancer Nanotherapy: Evolving Role of Multifunctional Nanoparticles for Cancer Active Targeting
1
Institute of Nano Science and Technology, Habitat Centre, Phase 10, Sector 64, Mohali 160062, Punjab, India
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Publication type: Journal Article
Publication date: 2019-07-24
scimago Q1
wos Q1
SJR: 1.801
CiteScore: 11.5
Impact factor: 6.8
ISSN: 00222623, 15204804
PubMed ID:
31339714
Drug Discovery
Molecular Medicine
Abstract
Nanoparticles with multifunctionality are being designed and formulated to overcome various limitations of drugs as well as conventional drug delivery systems. Engineered nanoparticles to specifically target cancer cells have the ability to reduce collateral damage on normal tissue due to pan-toxic effects of drugs. Pragmatic approaches are being in consideration to make advancement in cancer therapy as the new developed methods exhibited an improved targeted anticancer therapeutic delivery with better treatment outcomes. An effective cancer therapy requires both the passive and active targeting to successfully achieve targeted delivery. The nanoparticles can be conjugated with specific ligands, antibodies and carbohydrates for active targeting of cancer cells with great affinity and precision. This review presents some recent strategies such as immunotherapy, role of cell sex and protein corona in for targeted cancer therapy and also discusses some examples of engineered nanoparticles exploited for active cancer targeting and their limitations and associated toxicity.
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161
Total citations:
161
Citations from 2024:
62
(38%)
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MLA
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GOST
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Ahmad A. et al. Precision Cancer Nanotherapy: Evolving Role of Multifunctional Nanoparticles for Cancer Active Targeting // Journal of Medicinal Chemistry. 2019. Vol. 62. No. 23. pp. 10475-10496.
GOST all authors (up to 50)
Copy
Ahmad A., Khan F., Mishra R., Khan R. Precision Cancer Nanotherapy: Evolving Role of Multifunctional Nanoparticles for Cancer Active Targeting // Journal of Medicinal Chemistry. 2019. Vol. 62. No. 23. pp. 10475-10496.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.jmedchem.9b00511
UR - https://doi.org/10.1021/acs.jmedchem.9b00511
TI - Precision Cancer Nanotherapy: Evolving Role of Multifunctional Nanoparticles for Cancer Active Targeting
T2 - Journal of Medicinal Chemistry
AU - Ahmad, Anas
AU - Khan, Farheen
AU - Mishra, Rakesh
AU - Khan, Rehan
PY - 2019
DA - 2019/07/24
PB - American Chemical Society (ACS)
SP - 10475-10496
IS - 23
VL - 62
PMID - 31339714
SN - 0022-2623
SN - 1520-4804
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2019_Ahmad,
author = {Anas Ahmad and Farheen Khan and Rakesh Mishra and Rehan Khan},
title = {Precision Cancer Nanotherapy: Evolving Role of Multifunctional Nanoparticles for Cancer Active Targeting},
journal = {Journal of Medicinal Chemistry},
year = {2019},
volume = {62},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021/acs.jmedchem.9b00511},
number = {23},
pages = {10475--10496},
doi = {10.1021/acs.jmedchem.9b00511}
}
Cite this
MLA
Copy
Ahmad, Anas, et al. “Precision Cancer Nanotherapy: Evolving Role of Multifunctional Nanoparticles for Cancer Active Targeting.” Journal of Medicinal Chemistry, vol. 62, no. 23, Jul. 2019, pp. 10475-10496. https://doi.org/10.1021/acs.jmedchem.9b00511.
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