Total Synthesis of Natural Lembehyne C and Investigation of Its Cytotoxic Properties
Тип публикации: Journal Article
Дата публикации: 2020-07-16
SCImago Q1
WOS Q2
БС1
SJR: 0.585
CiteScore: 6.3
Impact factor: 3.7
ISSN: 01633864, 15206025
PubMed ID:
32672460
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Краткое описание
The first Z-stereoselective method for the synthesis of the natural marine alkynol lembehyne C, containing a 1Z,5Z,9Z-triene moiety, in 41% yield was developed using the new Ti-catalyzed cross-coupling of oxygenated and aliphatic 1,2-dienes as the key step. It was found for the first time that lembehyne C exhibits moderate cytotoxicity against Jurkat, K562, U937, and HL60 cancer cells and also efficiently induces apoptosis in Jurkat cells, with the cell death mechanism being activated by the mitochondrial pathway. The lembehyne C inhibition of the cell cycle follows the mitotic catastrophe mechanism.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Для доступа к списку цитирований публикации необходимо авторизоваться.
Для доступа к списку профилей, цитирующих публикацию, необходимо авторизоваться.
Топ-30
Журналы
|
1
2
|
|
|
Bioorganic Chemistry
2 публикации, 7.69%
|
|
|
The 26th International Electronic Conference on Synthetic Organic Chemistry
2 публикации, 7.69%
|
|
|
Phytochemistry Reviews
1 публикация, 3.85%
|
|
|
ChemistrySelect
1 публикация, 3.85%
|
|
|
ACS Catalysis
1 публикация, 3.85%
|
|
|
Chemical Science
1 публикация, 3.85%
|
|
|
Natural Product Reports
1 публикация, 3.85%
|
|
|
Synthesis
1 публикация, 3.85%
|
|
|
Organic Letters
1 публикация, 3.85%
|
|
|
ChemCatChem
1 публикация, 3.85%
|
|
|
Science China Chemistry
1 публикация, 3.85%
|
|
|
ACS Omega
1 публикация, 3.85%
|
|
|
Organic Chemistry Frontiers
1 публикация, 3.85%
|
|
|
Angewandte Chemie - International Edition
1 публикация, 3.85%
|
|
|
Angewandte Chemie
1 публикация, 3.85%
|
|
|
European Journal of Organic Chemistry
1 публикация, 3.85%
|
|
|
Russian Journal of Organic Chemistry
1 публикация, 3.85%
|
|
|
Russian Chemical Reviews
1 публикация, 3.85%
|
|
|
Chinese Journal of Chemistry
1 публикация, 3.85%
|
|
|
Synlett
1 публикация, 3.85%
|
|
|
Solid Fuel Chemistry
1 публикация, 3.85%
|
|
|
1
2
|
Издатели
|
1
2
3
4
5
6
7
|
|
|
Wiley
7 публикаций, 26.92%
|
|
|
MDPI
4 публикации, 15.38%
|
|
|
American Chemical Society (ACS)
3 публикации, 11.54%
|
|
|
Royal Society of Chemistry (RSC)
3 публикации, 11.54%
|
|
|
Springer Nature
2 публикации, 7.69%
|
|
|
Elsevier
2 публикации, 7.69%
|
|
|
Georg Thieme Verlag KG
2 публикации, 7.69%
|
|
|
Pleiades Publishing
1 публикация, 3.85%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 публикация, 3.85%
|
|
|
Allerton Press
1 публикация, 3.85%
|
|
|
1
2
3
4
5
6
7
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Войти с ORCID
Метрики
26
Всего цитирований:
26
Цитирований c 2025:
4
(15.38%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Dzhemileva L. U. et al. Total Synthesis of Natural Lembehyne C and Investigation of Its Cytotoxic Properties // Journal of Natural Products. 2020. Vol. 83. No. 8. pp. 2399-2409.
ГОСТ со всеми авторами (до 50)
Скопировать
Dzhemileva L. U., D'yakonov V. A., Makarov A. A., Makarova E. Kh., Andreev E. N., Dzhemilev U. M. Total Synthesis of Natural Lembehyne C and Investigation of Its Cytotoxic Properties // Journal of Natural Products. 2020. Vol. 83. No. 8. pp. 2399-2409.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1021/acs.jnatprod.0c00261
UR - https://doi.org/10.1021/acs.jnatprod.0c00261
TI - Total Synthesis of Natural Lembehyne C and Investigation of Its Cytotoxic Properties
T2 - Journal of Natural Products
AU - Dzhemileva, Lilya U.
AU - D'yakonov, Vladimir A
AU - Makarov, Alexey A
AU - Makarova, Elina Kh
AU - Andreev, Evgeny N
AU - Dzhemilev, Usein M
PY - 2020
DA - 2020/07/16
PB - American Chemical Society (ACS)
SP - 2399-2409
IS - 8
VL - 83
PMID - 32672460
SN - 0163-3864
SN - 1520-6025
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2020_Dzhemileva,
author = {Lilya U. Dzhemileva and Vladimir A D'yakonov and Alexey A Makarov and Elina Kh Makarova and Evgeny N Andreev and Usein M Dzhemilev},
title = {Total Synthesis of Natural Lembehyne C and Investigation of Its Cytotoxic Properties},
journal = {Journal of Natural Products},
year = {2020},
volume = {83},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021/acs.jnatprod.0c00261},
number = {8},
pages = {2399--2409},
doi = {10.1021/acs.jnatprod.0c00261}
}
Цитировать
MLA
Скопировать
Dzhemileva, Lilya U., et al. “Total Synthesis of Natural Lembehyne C and Investigation of Its Cytotoxic Properties.” Journal of Natural Products, vol. 83, no. 8, Jul. 2020, pp. 2399-2409. https://doi.org/10.1021/acs.jnatprod.0c00261.
Профили
Ошибка в публикации?