Antiplasmodial Chromanes and Chromenes from the Monotypic Plant Species Koeberlinia spinosa
2
Natural Products Discovery Institute, 3805 Old Easton Road, Doylestown, Pennsylvania 18902, United States
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Publication type: Journal Article
Publication date: 2017-10-19
scimago Q1
wos Q1
SJR: 0.629
CiteScore: 6.5
Impact factor: 3.6
ISSN: 01633864, 15206025
PubMed ID:
29048892
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
Nine new compounds containing either a chromane or chromene ring moiety were isolated from the monotypic plant Koeberlinia spinosa. Compounds 1-4 are chromanes with all possible E and Z isomers of the isoprenoid side chain, with compound 5 a methylated derivative of 1. Compounds 6 and 7 were assigned as diastereomeric cyclized derivatives of 2 and were probably artifacts formed during the extraction or the isolation processes. Compounds 8 and 9 were characterized as new chromenes. Structure elucidation of 1-9 was conducted via 1D and 2D NMR spectroscopic data interpretation, and absolute configurations were determined by ECD spectroscopic analysis. Compounds 2, 5, 6, and 7 had weak antiplasmodial activity, while none of the compounds exhibited antiproliferative activity. The isolation, structure elucidation, and biological evaluation of these compounds are presented.
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19
Total citations:
19
Citations from 2024:
5
(26%)
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GOST
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Presley C. C. et al. Antiplasmodial Chromanes and Chromenes from the Monotypic Plant Species Koeberlinia spinosa // Journal of Natural Products. 2017. Vol. 81. No. 3. pp. 475-483.
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Valenciano A. L., Cassera M. B., Goetz M., Clement J. A. Antiplasmodial Chromanes and Chromenes from the Monotypic Plant Species Koeberlinia spinosa // Journal of Natural Products. 2017. Vol. 81. No. 3. pp. 475-483.
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RIS
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TY - JOUR
DO - 10.1021/acs.jnatprod.7b00579
UR - https://doi.org/10.1021/acs.jnatprod.7b00579
TI - Antiplasmodial Chromanes and Chromenes from the Monotypic Plant Species Koeberlinia spinosa
T2 - Journal of Natural Products
AU - Valenciano, Ana L
AU - Cassera, Maria Belen
AU - Goetz, Michael
AU - Clement, Jason A
PY - 2017
DA - 2017/10/19
PB - American Chemical Society (ACS)
SP - 475-483
IS - 3
VL - 81
PMID - 29048892
SN - 0163-3864
SN - 1520-6025
ER -
Cite this
BibTex (up to 50 authors)
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@article{2017_Presley,
author = {Ana L Valenciano and Maria Belen Cassera and Michael Goetz and Jason A Clement},
title = {Antiplasmodial Chromanes and Chromenes from the Monotypic Plant Species Koeberlinia spinosa},
journal = {Journal of Natural Products},
year = {2017},
volume = {81},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/acs.jnatprod.7b00579},
number = {3},
pages = {475--483},
doi = {10.1021/acs.jnatprod.7b00579}
}
Cite this
MLA
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Presley, Christopher Charles, et al. “Antiplasmodial Chromanes and Chromenes from the Monotypic Plant Species Koeberlinia spinosa.” Journal of Natural Products, vol. 81, no. 3, Oct. 2017, pp. 475-483. https://doi.org/10.1021/acs.jnatprod.7b00579.
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