Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca
Publication type: Journal Article
Publication date: 2018-03-13
scimago Q1
wos Q1
SJR: 0.629
CiteScore: 6.5
Impact factor: 3.6
ISSN: 01633864, 15206025
PubMed ID:
29533611
Organic Chemistry
Drug Discovery
Pharmacology
Pharmaceutical Science
Molecular Medicine
Complementary and alternative medicine
Analytical Chemistry
Abstract
Chemical investigation of the roots of the Australian desert plant Eremophila microtheca yielded microthecaline A (1), a novel quinoline-serrulatane natural product. The structure of 1 was determined by spectroscopic analysis, and the absolute configuration was assigned by ECD. Compound 1 exhibited moderate antimalarial activity against Plasmodium falciparum (3D7 strain), with an IC50 of 7.7 μM. Microthecaline A represents the first quinoline-serrulatane alkaloid to be isolated from Nature.
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Total citations:
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Citations from 2025:
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GOST
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Kumar R. et al. Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca // Journal of Natural Products. 2018. Vol. 81. No. 4. pp. 1079-1083.
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Kumar R., Duffy S., Avery V. M., Carroll A., Davis R. A. Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca // Journal of Natural Products. 2018. Vol. 81. No. 4. pp. 1079-1083.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.jnatprod.7b00992
UR - https://doi.org/10.1021/acs.jnatprod.7b00992
TI - Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca
T2 - Journal of Natural Products
AU - Kumar, Rohitesh
AU - Duffy, Sandra
AU - Avery, Vicky M.
AU - Carroll, Anthony
AU - Davis, Rohan A.
PY - 2018
DA - 2018/03/13
PB - American Chemical Society (ACS)
SP - 1079-1083
IS - 4
VL - 81
PMID - 29533611
SN - 0163-3864
SN - 1520-6025
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Kumar,
author = {Rohitesh Kumar and Sandra Duffy and Vicky M. Avery and Anthony Carroll and Rohan A. Davis},
title = {Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca},
journal = {Journal of Natural Products},
year = {2018},
volume = {81},
publisher = {American Chemical Society (ACS)},
month = {mar},
url = {https://doi.org/10.1021/acs.jnatprod.7b00992},
number = {4},
pages = {1079--1083},
doi = {10.1021/acs.jnatprod.7b00992}
}
Cite this
MLA
Copy
Kumar, Rohitesh, et al. “Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca.” Journal of Natural Products, vol. 81, no. 4, Mar. 2018, pp. 1079-1083. https://doi.org/10.1021/acs.jnatprod.7b00992.