Journal of Organic Chemistry, volume 86, issue 9, pages 6888-6896
An Isoxazole Strategy for the Synthesis of Fully Substituted Nicotinates
Publication type: Journal Article
Publication date: 2021-04-13
Journal:
Journal of Organic Chemistry
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 3.6
ISSN: 00223263, 15206904
Organic Chemistry
Abstract
A four-step quasi one-pot procedure for the preparation of fully substituted nicotinates from ketone enamines and 4-methylideneisoxazol-5-ones has been developed. The reaction sequence involves (1) reaction of 4-methylideneisoxazol-5-ones with ketone enamines with the formation of isoxazole-5-ols, (2) their O-methylation with diazomethane, (3) hydrogenative cleavage of the O-N bond in 5-methoxyisoxazoles under action of Mo(CO)6/H2O and simultaneous isomerization and condensation of the formed enamines, with the formation of dihydropyridines, and (4) aromatization of the latter.
Citations by journals
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2
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Journal of Organic Chemistry
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Journal of Organic Chemistry
2 publications, 18.18%
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Organic and Biomolecular Chemistry
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Organic and Biomolecular Chemistry
2 publications, 18.18%
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Tetrahedron Letters
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Tetrahedron Letters
1 publication, 9.09%
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Scientific Reports
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Scientific Reports
1 publication, 9.09%
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ACS Omega
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ACS Omega
1 publication, 9.09%
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Russian Journal of General Chemistry
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Russian Journal of General Chemistry
1 publication, 9.09%
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Research on Chemical Intermediates
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Research on Chemical Intermediates
1 publication, 9.09%
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ChemistrySelect
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ChemistrySelect
1 publication, 9.09%
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Sustainable Chemistry for the Environment
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Sustainable Chemistry for the Environment
1 publication, 9.09%
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2
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Citations by publishers
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3
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American Chemical Society (ACS)
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American Chemical Society (ACS)
3 publications, 27.27%
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Elsevier
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Elsevier
2 publications, 18.18%
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Springer Nature
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Springer Nature
2 publications, 18.18%
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Royal Society of Chemistry (RSC)
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Royal Society of Chemistry (RSC)
2 publications, 18.18%
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Pleiades Publishing
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Pleiades Publishing
1 publication, 9.09%
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Wiley
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Wiley
1 publication, 9.09%
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1
2
3
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Galenko E. E. et al. An Isoxazole Strategy for the Synthesis of Fully Substituted Nicotinates // Journal of Organic Chemistry. 2021. Vol. 86. No. 9. pp. 6888-6896.
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Galenko E. E., Kryukova M. A., Novikov M. S., Khlebnikov A. F. An Isoxazole Strategy for the Synthesis of Fully Substituted Nicotinates // Journal of Organic Chemistry. 2021. Vol. 86. No. 9. pp. 6888-6896.
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TY - JOUR
DO - 10.1021/acs.joc.1c00286
UR - https://doi.org/10.1021%2Facs.joc.1c00286
TI - An Isoxazole Strategy for the Synthesis of Fully Substituted Nicotinates
T2 - Journal of Organic Chemistry
AU - Galenko, Ekaterina E
AU - Kryukova, Mariya A
AU - Novikov, Mikhail S.
AU - Khlebnikov, Alexander F
PY - 2021
DA - 2021/04/13 00:00:00
PB - American Chemical Society (ACS)
SP - 6888-6896
IS - 9
VL - 86
SN - 0022-3263
SN - 1520-6904
ER -
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@article{2021_Galenko,
author = {Ekaterina E Galenko and Mariya A Kryukova and Mikhail S. Novikov and Alexander F Khlebnikov},
title = {An Isoxazole Strategy for the Synthesis of Fully Substituted Nicotinates},
journal = {Journal of Organic Chemistry},
year = {2021},
volume = {86},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021%2Facs.joc.1c00286},
number = {9},
pages = {6888--6896},
doi = {10.1021/acs.joc.1c00286}
}
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MLA
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Galenko, Ekaterina E., et al. “An Isoxazole Strategy for the Synthesis of Fully Substituted Nicotinates.” Journal of Organic Chemistry, vol. 86, no. 9, Apr. 2021, pp. 6888-6896. https://doi.org/10.1021%2Facs.joc.1c00286.