volume 84 issue 22 pages 14868-14882

Synthesis of Cyclic Alkenyl Dimethylsiloxanes from Alkynyl Benzyldimethylsilanes and Application in Polyene Synthesis

Haraldur G Gudmundsson 1
Christian J Kuper 1
F. Bonnete 1
Felix Urbitsch 1
Bryony L Elbert 1
1
 
Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, U.K.
Publication typeJournal Article
Publication date2019-10-24
scimago Q2
wos Q1
SJR0.737
CiteScore6.1
Impact factor3.6
ISSN00223263, 15206904
Organic Chemistry
Abstract
Cyclic dimethylalkenylsiloxanes, useful motifs for (Z)-selective Hiyama cross-coupling, are accessed from alkynyl benzyldimethylsilanes featuring adjacent allylic or homoallylic oxygen substituents by semihydrogenation/debenzylation/cyclization. While formation of 5- and 6-membered rings can be achieved from the free alcohols using fluoride or silanolate, allylic acetate precursors to 5-membered rings display distinct modes of activation. The utility of these compounds is demonstrated through the preparation of a variety of (Z)-alkene-containing polyenes and application to a concise total synthesis of leukotriene B3.
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Gudmundsson H. G. et al. Synthesis of Cyclic Alkenyl Dimethylsiloxanes from Alkynyl Benzyldimethylsilanes and Application in Polyene Synthesis // Journal of Organic Chemistry. 2019. Vol. 84. No. 22. pp. 14868-14882.
GOST all authors (up to 50) Copy
Gudmundsson H. G., Kuper C. J., Bonnete F., Urbitsch F., Elbert B. L., ANDERSON E. Synthesis of Cyclic Alkenyl Dimethylsiloxanes from Alkynyl Benzyldimethylsilanes and Application in Polyene Synthesis // Journal of Organic Chemistry. 2019. Vol. 84. No. 22. pp. 14868-14882.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1021/acs.joc.9b01664
UR - https://doi.org/10.1021/acs.joc.9b01664
TI - Synthesis of Cyclic Alkenyl Dimethylsiloxanes from Alkynyl Benzyldimethylsilanes and Application in Polyene Synthesis
T2 - Journal of Organic Chemistry
AU - Gudmundsson, Haraldur G
AU - Kuper, Christian J
AU - Bonnete, F.
AU - Urbitsch, Felix
AU - Elbert, Bryony L
AU - ANDERSON, EDWARD F.
PY - 2019
DA - 2019/10/24
PB - American Chemical Society (ACS)
SP - 14868-14882
IS - 22
VL - 84
PMID - 31646859
SN - 0022-3263
SN - 1520-6904
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2019_Gudmundsson,
author = {Haraldur G Gudmundsson and Christian J Kuper and F. Bonnete and Felix Urbitsch and Bryony L Elbert and EDWARD F. ANDERSON},
title = {Synthesis of Cyclic Alkenyl Dimethylsiloxanes from Alkynyl Benzyldimethylsilanes and Application in Polyene Synthesis},
journal = {Journal of Organic Chemistry},
year = {2019},
volume = {84},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/acs.joc.9b01664},
number = {22},
pages = {14868--14882},
doi = {10.1021/acs.joc.9b01664}
}
MLA
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MLA Copy
Gudmundsson, Haraldur G., et al. “Synthesis of Cyclic Alkenyl Dimethylsiloxanes from Alkynyl Benzyldimethylsilanes and Application in Polyene Synthesis.” Journal of Organic Chemistry, vol. 84, no. 22, Oct. 2019, pp. 14868-14882. https://doi.org/10.1021/acs.joc.9b01664.