Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange
Johannes F. P. Colell
1
,
Angus W J Logan
1
,
Zijian Zhou
1
,
Roman Shchepin
2
,
Danila A. Barskiy
2
,
Gerardo X Ortiz
1
,
Qiu Wang
1
,
Steven J Malcolmson
1
,
Eduard Chekmenev
2, 3
,
W. Warren
1, 4
,
Thomas Theis
1
3
Russian Academy of Sciences, MOSCOW, Russia
|
Publication type: Journal Article
Publication date: 2017-02-16
scimago Q1
wos Q3
SJR: 0.914
CiteScore: 6.2
Impact factor: 3.2
ISSN: 19327447, 19327455
PubMed ID:
28392884
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Physical and Theoretical Chemistry
General Energy
Abstract
Signal Amplification by Reversible Exchange (SABRE) is a fast and convenient NMR hyperpolarization method that uses cheap and readily available para-hydrogen as a hyperpolarization source. SABRE can hyperpolarize protons and heteronuclei. Here we focus on the heteronuclear variant introduced as SABRE-SHEATH (SABRE in SHield Enables Alignment Transfer to Heteronuclei) and nitrogen-15 targets in particular. We show that 15N-SABRE works more efficiently and on a wider range of substrates than 1H-SABRE, greatly generalizing the SABRE approach. In addition, we show that nitrogen-15 offers significantly extended T1 times of up to 12 minutes. Long T1 times enable higher hyperpolarization levels but also hold the promise of hyperpolarized molecular imaging for several tens of minutes. Detailed characterization and optimization are presented, leading to nitrogen-15 polarization levels in excess of 10% on several compounds.
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Colell J. F. P. et al. Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange // Journal of Physical Chemistry C. 2017. Vol. 121. No. 12. pp. 6626-6634.
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Colell J. F. P., Logan A. W. J., Zhou Z., Shchepin R., Barskiy D. A., Ortiz G. X., Wang Q., Malcolmson S. J., Chekmenev E., Warren W., Theis T. Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange // Journal of Physical Chemistry C. 2017. Vol. 121. No. 12. pp. 6626-6634.
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TY - JOUR
DO - 10.1021/acs.jpcc.6b12097
UR - https://doi.org/10.1021/acs.jpcc.6b12097
TI - Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange
T2 - Journal of Physical Chemistry C
AU - Colell, Johannes F. P.
AU - Logan, Angus W J
AU - Zhou, Zijian
AU - Shchepin, Roman
AU - Barskiy, Danila A.
AU - Ortiz, Gerardo X
AU - Wang, Qiu
AU - Malcolmson, Steven J
AU - Chekmenev, Eduard
AU - Warren, W.
AU - Theis, Thomas
PY - 2017
DA - 2017/02/16
PB - American Chemical Society (ACS)
SP - 6626-6634
IS - 12
VL - 121
PMID - 28392884
SN - 1932-7447
SN - 1932-7455
ER -
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BibTex (up to 50 authors)
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@article{2017_Colell,
author = {Johannes F. P. Colell and Angus W J Logan and Zijian Zhou and Roman Shchepin and Danila A. Barskiy and Gerardo X Ortiz and Qiu Wang and Steven J Malcolmson and Eduard Chekmenev and W. Warren and Thomas Theis},
title = {Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange},
journal = {Journal of Physical Chemistry C},
year = {2017},
volume = {121},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://doi.org/10.1021/acs.jpcc.6b12097},
number = {12},
pages = {6626--6634},
doi = {10.1021/acs.jpcc.6b12097}
}
Cite this
MLA
Copy
Colell, Johannes F. P., et al. “Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange.” Journal of Physical Chemistry C, vol. 121, no. 12, Feb. 2017, pp. 6626-6634. https://doi.org/10.1021/acs.jpcc.6b12097.