Overview of Recent Scale-Ups in Organic Electrosynthesis (2000–2023)
1
Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States
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Publication type: Journal Article
Publication date: 2024-01-18
scimago Q1
wos Q1
SJR: 0.865
CiteScore: 5.4
Impact factor: 3.5
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
This review summarizes examples of organic electrosynthesis from the peer-reviewed literature from 2000 to 2023 that have been conducted on scales of 20 g or above. A significant portion of these examples were conducted on a ≤100 g scale, while detailed reports of kilogram-scale electrosynthesis remain scarce in the pharmaceutical industry. In addition to the chemical transformation, this review also highlights the type of reactor used and a projected productivity metric as ways to compare the different reports. The selected examples of organic electrosynthesis scale-ups described herein also illustrate the remaining challenges currently preventing the routine use of large-scale electrosynthesis in the pharmaceutical industry.
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Citations from 2025:
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GOST
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Lehnherr D., Chen L. Overview of Recent Scale-Ups in Organic Electrosynthesis (2000–2023) // Organic Process Research and Development. 2024. Vol. 28. No. 2. pp. 338-366.
GOST all authors (up to 50)
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Lehnherr D., Chen L. Overview of Recent Scale-Ups in Organic Electrosynthesis (2000–2023) // Organic Process Research and Development. 2024. Vol. 28. No. 2. pp. 338-366.
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TY - JOUR
DO - 10.1021/acs.oprd.3c00340
UR - https://pubs.acs.org/doi/10.1021/acs.oprd.3c00340
TI - Overview of Recent Scale-Ups in Organic Electrosynthesis (2000–2023)
T2 - Organic Process Research and Development
AU - Lehnherr, Dan
AU - Chen, Longrui
PY - 2024
DA - 2024/01/18
PB - American Chemical Society (ACS)
SP - 338-366
IS - 2
VL - 28
SN - 1083-6160
SN - 1520-586X
ER -
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BibTex (up to 50 authors)
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@article{2024_Lehnherr,
author = {Dan Lehnherr and Longrui Chen},
title = {Overview of Recent Scale-Ups in Organic Electrosynthesis (2000–2023)},
journal = {Organic Process Research and Development},
year = {2024},
volume = {28},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://pubs.acs.org/doi/10.1021/acs.oprd.3c00340},
number = {2},
pages = {338--366},
doi = {10.1021/acs.oprd.3c00340}
}
Cite this
MLA
Copy
Lehnherr, Dan, and Longrui Chen. “Overview of Recent Scale-Ups in Organic Electrosynthesis (2000–2023).” Organic Process Research and Development, vol. 28, no. 2, Jan. 2024, pp. 338-366. https://pubs.acs.org/doi/10.1021/acs.oprd.3c00340.