Ring-Closing Metathesis in Pharmaceutical Development: Fundamentals, Applications, and Future Directions
Publication type: Journal Article
Publication date: 2018-06-22
scimago Q1
wos Q1
SJR: 0.865
CiteScore: 5.4
Impact factor: 3.5
ISSN: 10836160, 1520586X
Organic Chemistry
Physical and Theoretical Chemistry
Abstract
Ring-closing metathesis (RCM) has become indispensable in organic synthesis for both academic investigations and industrial applications. This review provides an overview of RCM reactions, focusing on the practical aspects that researchers in an industrial environment may find of interest. Key elements of reaction design and lessons learned from these applications are discussed to help those considering implementing RCM reactions on scale, particularly in manufacturing active pharmaceutical ingredients (APIs). Advances in the development of more effective catalysts and new methodologies, such as enantioselective RCM and stereoselective macrocyclic RCM, are also briefly discussed.
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Metrics
100
Total citations:
100
Citations from 2024:
29
(29%)
Cite this
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MLA
Cite this
GOST
Copy
Yu M., Lou S., González Bobes F. Ring-Closing Metathesis in Pharmaceutical Development: Fundamentals, Applications, and Future Directions // Organic Process Research and Development. 2018. Vol. 22. No. 8. pp. 918-946.
GOST all authors (up to 50)
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Yu M., Lou S., González Bobes F. Ring-Closing Metathesis in Pharmaceutical Development: Fundamentals, Applications, and Future Directions // Organic Process Research and Development. 2018. Vol. 22. No. 8. pp. 918-946.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.oprd.8b00093
UR - https://doi.org/10.1021/acs.oprd.8b00093
TI - Ring-Closing Metathesis in Pharmaceutical Development: Fundamentals, Applications, and Future Directions
T2 - Organic Process Research and Development
AU - Yu, Miao
AU - Lou, Sha
AU - González Bobes, Francisco
PY - 2018
DA - 2018/06/22
PB - American Chemical Society (ACS)
SP - 918-946
IS - 8
VL - 22
SN - 1083-6160
SN - 1520-586X
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Yu,
author = {Miao Yu and Sha Lou and Francisco González Bobes},
title = {Ring-Closing Metathesis in Pharmaceutical Development: Fundamentals, Applications, and Future Directions},
journal = {Organic Process Research and Development},
year = {2018},
volume = {22},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021/acs.oprd.8b00093},
number = {8},
pages = {918--946},
doi = {10.1021/acs.oprd.8b00093}
}
Cite this
MLA
Copy
Yu., Miao, et al. “Ring-Closing Metathesis in Pharmaceutical Development: Fundamentals, Applications, and Future Directions.” Organic Process Research and Development, vol. 22, no. 8, Jun. 2018, pp. 918-946. https://doi.org/10.1021/acs.oprd.8b00093.