Sequential DNA-Encoded Building Block Fusion for the Construction of Polysubstituted Pyrazoline Core Libraries
Publication type: Journal Article
Publication date: 2021-10-15
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
34652930
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
The construction of chemical libraries containing polysubstituted pyrazoline scaffolds is highly desirable for the discovery of novel chemical ligands for biological targets. Herein, we report a sequential DNA-encoded synthesis strategy for polysubstituted pyrazoline heterocycles, which fuses a broad panel of aldehydes, aryl amines, and alkenes as building blocks. Furthermore, mock library synthesis and selection demonstrated the ability of the method to produce DNA-encoded focused libraries with highly functionalized pyrazoline cores.
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Metrics
38
Total citations:
38
Citations from 2025:
10
(26.32%)
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MLA
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GOST
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Juan Z. et al. Sequential DNA-Encoded Building Block Fusion for the Construction of Polysubstituted Pyrazoline Core Libraries // Organic Letters. 2021. Vol. 23. No. 21. pp. 8429-8433.
GOST all authors (up to 50)
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Juan Z., Li X., Wei H., Li Y., Zhang G., Yizhou Li 李. Sequential DNA-Encoded Building Block Fusion for the Construction of Polysubstituted Pyrazoline Core Libraries // Organic Letters. 2021. Vol. 23. No. 21. pp. 8429-8433.
Cite this
RIS
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TY - JOUR
DO - 10.1021/acs.orglett.1c03145
UR - https://doi.org/10.1021/acs.orglett.1c03145
TI - Sequential DNA-Encoded Building Block Fusion for the Construction of Polysubstituted Pyrazoline Core Libraries
T2 - Organic Letters
AU - Juan, ZHANG
AU - Li, Xianfeng
AU - Wei, Haimei
AU - Li, Yangfeng
AU - Zhang, Gong
AU - Yizhou Li, 李乙洲
PY - 2021
DA - 2021/10/15
PB - American Chemical Society (ACS)
SP - 8429-8433
IS - 21
VL - 23
PMID - 34652930
SN - 1523-7060
SN - 1523-7052
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2021_Juan,
author = {ZHANG Juan and Xianfeng Li and Haimei Wei and Yangfeng Li and Gong Zhang and 李乙洲 Yizhou Li},
title = {Sequential DNA-Encoded Building Block Fusion for the Construction of Polysubstituted Pyrazoline Core Libraries},
journal = {Organic Letters},
year = {2021},
volume = {23},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/acs.orglett.1c03145},
number = {21},
pages = {8429--8433},
doi = {10.1021/acs.orglett.1c03145}
}
Cite this
MLA
Copy
Juan, ZHANG, et al. “Sequential DNA-Encoded Building Block Fusion for the Construction of Polysubstituted Pyrazoline Core Libraries.” Organic Letters, vol. 23, no. 21, Oct. 2021, pp. 8429-8433. https://doi.org/10.1021/acs.orglett.1c03145.