Organic Letters, volume 24, issue 36, pages 6692-6696

Palladium-Catalyzed Nucleophilic Reaction of Alkylidenecyclopropanes with β,γ-Unsaturated α-Ketoesters: Ligand-Controlled Divergent Synthesis

Xin Lian Liu 1
You Ya Zhang 1
Lin Li 1
Lu Qi Tan 1
Yin Ai Huang 1
Ai-Jun Ma 1
Jin-Bao Peng 1
Publication typeJournal Article
Publication date2022-09-07
Journal: Organic Letters
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor5.2
ISSN15237060, 15237052
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
A palladium-catalyzed ligand-controlled selective 1,4-addition and cycloaddition reaction of β,γ-unsaturated α-ketoesters with alkylidenecyclopropanes (ACPs) has been developed. Using ACPs and β,γ-unsaturated α-ketoesters as starting materials, γ-dienyl-α-ketoesters and dihydro-2H-pyrans could be prepared selectively by modulating the ligand. A range of multisubstituted α-ketoesters and dihydro-2H-pyrans were obtained in moderate to excellent yields with excellent regioselectivities.

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GOST |
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GOST Copy
Liu X. L. et al. Palladium-Catalyzed Nucleophilic Reaction of Alkylidenecyclopropanes with β,γ-Unsaturated α-Ketoesters: Ligand-Controlled Divergent Synthesis // Organic Letters. 2022. Vol. 24. No. 36. pp. 6692-6696.
GOST all authors (up to 50) Copy
Liu X. L., Zhang Y. Ya., Li L., Tan L. Q., Huang Y. A., Ma A., Peng J. Palladium-Catalyzed Nucleophilic Reaction of Alkylidenecyclopropanes with β,γ-Unsaturated α-Ketoesters: Ligand-Controlled Divergent Synthesis // Organic Letters. 2022. Vol. 24. No. 36. pp. 6692-6696.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1021/acs.orglett.2c02839
UR - https://doi.org/10.1021/acs.orglett.2c02839
TI - Palladium-Catalyzed Nucleophilic Reaction of Alkylidenecyclopropanes with β,γ-Unsaturated α-Ketoesters: Ligand-Controlled Divergent Synthesis
T2 - Organic Letters
AU - Liu, Xin Lian
AU - Zhang, You Ya
AU - Li, Lin
AU - Tan, Lu Qi
AU - Huang, Yin Ai
AU - Ma, Ai-Jun
AU - Peng, Jin-Bao
PY - 2022
DA - 2022/09/07 00:00:00
PB - American Chemical Society (ACS)
SP - 6692-6696
IS - 36
VL - 24
SN - 1523-7060
SN - 1523-7052
ER -
BibTex |
Cite this
BibTex Copy
@article{2022_Liu,
author = {Xin Lian Liu and You Ya Zhang and Lin Li and Lu Qi Tan and Yin Ai Huang and Ai-Jun Ma and Jin-Bao Peng},
title = {Palladium-Catalyzed Nucleophilic Reaction of Alkylidenecyclopropanes with β,γ-Unsaturated α-Ketoesters: Ligand-Controlled Divergent Synthesis},
journal = {Organic Letters},
year = {2022},
volume = {24},
publisher = {American Chemical Society (ACS)},
month = {sep},
url = {https://doi.org/10.1021/acs.orglett.2c02839},
number = {36},
pages = {6692--6696},
doi = {10.1021/acs.orglett.2c02839}
}
MLA
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MLA Copy
Liu, Xin Lian, et al. “Palladium-Catalyzed Nucleophilic Reaction of Alkylidenecyclopropanes with β,γ-Unsaturated α-Ketoesters: Ligand-Controlled Divergent Synthesis.” Organic Letters, vol. 24, no. 36, Sep. 2022, pp. 6692-6696. https://doi.org/10.1021/acs.orglett.2c02839.
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