Organic Letters

, volume 17 , issue 21 , pages 5484-5487

Intramolecular Friedel–Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol

Hashim F. Motiwala ¹

Rakesh H Vekariya ¹

Jeffrey Aubé ¹

Hide authors affiliations Show authors affiliations: 1 affiliation

Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66047, United States |

Publication type: Journal Article

Publication date: 2015-10-23

American Chemical Society (ACS)

Organic Letters

scimago Q1

wos Q1

SJR: 1.235

CiteScore: 8.7

Impact factor: 5.0

ISSN: 15237060, 15237052

DOI: 10.1021/acs.orglett.5b02851

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PubMed ID: 26496158

Organic Chemistry

Biochemistry

Physical and Theoretical Chemistry

Abstract

Simple dissolution of an arylalkyl acid chloride in 1,1,1,3,3,3-hexafluoro-2-propanol promotes an intramolecular Friedel-Crafts acylation without additional catalysts or reagents. This reaction is operationally trivial in both execution and product isolation (only requiring concentration followed by purification) and accommodates a broad range of substrates. Preliminary studies that bear upon potential reaction mechanisms are reported.

Found

1 citation

Uchuskin Maxim

🥼 🤝

PhD in Chemistry

56 publications, 778 citations

h-index: 16

Perm State National Research University

Research interests

Heterocyclic compounds

Organic synthesis

Synthetic Organic Chemistry

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Motiwala H. F., Vekariya R. H., Aubé J. Intramolecular Friedel–Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol // Organic Letters. 2015. Vol. 17. No. 21. pp. 5484-5487.

GOST all authors (up to 50) Copy

Motiwala H. F., Vekariya R. H., Aubé J. Intramolecular Friedel–Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol // Organic Letters. 2015. Vol. 17. No. 21. pp. 5484-5487.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/acs.orglett.5b02851

UR - https://doi.org/10.1021/acs.orglett.5b02851

TI - Intramolecular Friedel–Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol

T2 - Organic Letters

AU - Motiwala, Hashim F.

AU - Vekariya, Rakesh H

AU - Aubé, Jeffrey

PY - 2015

DA - 2015/10/23

PB - American Chemical Society (ACS)

SP - 5484-5487

IS - 21

VL - 17

PMID - 26496158

SN - 1523-7060

SN - 1523-7052

ER -

BibTex |

Cite this

BibTex (up to 50 authors) Copy

@article{2015_Motiwala,

author = {Hashim F. Motiwala and Rakesh H Vekariya and Jeffrey Aubé},

title = {Intramolecular Friedel–Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol},

journal = {Organic Letters},

year = {2015},

volume = {17},

publisher = {American Chemical Society (ACS)},

month = {oct},

url = {https://doi.org/10.1021/acs.orglett.5b02851},

number = {21},

pages = {5484--5487},

doi = {10.1021/acs.orglett.5b02851}

}

MLA

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MLA Copy

Motiwala, Hashim F., et al. “Intramolecular Friedel–Crafts Acylation Reaction Promoted by 1,1,1,3,3,3-Hexafluoro-2-propanol.” Organic Letters, vol. 17, no. 21, Oct. 2015, pp. 5484-5487. https://doi.org/10.1021/acs.orglett.5b02851.

Publisher

American Chemical Society (ACS)

Journal

Organic Letters

scimago Q1

wos Q1

SJR

1.235

CiteScore

8.7

Impact factor

5.0

ISSN

15237060 (Print)

15237052 (Electronic)