Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy
Publication type: Journal Article
Publication date: 2015-12-10
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
26651162
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
An efficient strategy for the one-pot synthesis of polysubstituted pyridines via a cascade reaction from aldehydes, phosphorus ylides, and propargyl azide is reported. The reaction sequence involves a Wittig reaction, a Staudinger reaction, an aza-Wittig reaction, a 6π-3-azatriene electrocyclization, and a 1,3-H shift. This protocol provides quick access to the polysubstituted pyridines from readily available substrates in good to excellent yields.
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Metrics
78
Total citations:
78
Citations from 2025:
6
(7.69%)
Cite this
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BibTex |
MLA
Cite this
GOST
Copy
Wei H. et al. Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy // Organic Letters. 2015. Vol. 17. No. 24. pp. 5974-5977.
GOST all authors (up to 50)
Copy
Wei H., Li Y., Xiao K., Cheng B., Wang H., Hu L., Zhai H. Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy // Organic Letters. 2015. Vol. 17. No. 24. pp. 5974-5977.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.orglett.5b02903
UR - https://doi.org/10.1021/acs.orglett.5b02903
TI - Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy
T2 - Organic Letters
AU - Wei, Hongbo
AU - Li, Yun
AU - Xiao, Ke
AU - Cheng, Bin
AU - Wang, Huifei
AU - Hu, Lin
AU - Zhai, Hongbin
PY - 2015
DA - 2015/12/10
PB - American Chemical Society (ACS)
SP - 5974-5977
IS - 24
VL - 17
PMID - 26651162
SN - 1523-7060
SN - 1523-7052
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2015_Wei,
author = {Hongbo Wei and Yun Li and Ke Xiao and Bin Cheng and Huifei Wang and Lin Hu and Hongbin Zhai},
title = {Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy},
journal = {Organic Letters},
year = {2015},
volume = {17},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/acs.orglett.5b02903},
number = {24},
pages = {5974--5977},
doi = {10.1021/acs.orglett.5b02903}
}
Cite this
MLA
Copy
Wei, Hongbo, et al. “Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy.” Organic Letters, vol. 17, no. 24, Dec. 2015, pp. 5974-5977. https://doi.org/10.1021/acs.orglett.5b02903.