, volume 19 , issue 20 , pages 5649-5652

An Intermolecular Azidoheteroarylation of Simple Alkenes via Free-Radical Multicomponent Cascade Reactions

Zhongquan Liu ^{1, 2}

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State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China |

State Key Laboratory Cultivation Base for TCM Quality and Efficacy, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China |

Publication type: Journal Article

Publication date: 2017-09-29

American Chemical Society (ACS)

Organic Letters

scimago Q1

wos Q1

SJR: 1.235

CiteScore: 8.7

Impact factor: 5.0

ISSN: 15237060, 15237052

DOI: 10.1021/acs.orglett.7b02788

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PubMed ID: 28961001

Organic Chemistry

Biochemistry

Physical and Theoretical Chemistry

Abstract

Based upon a radical polar effect, an intermolecular azidoheteroarylation of simple alkenes via a metal-free radical multicomponent cascade process was achieved. It allows a mild, rapid, and step-economic access to a broad range of azidoalkylated heteroaromatics. Given the diversity in transformations of organic azides and medicinally privileged scaffolds of heteroarenes, this strategy enables efficient synthesis and late-stage derivatization of drugs and candidates.

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Liu Z. An Intermolecular Azidoheteroarylation of Simple Alkenes via Free-Radical Multicomponent Cascade Reactions // Organic Letters. 2017. Vol. 19. No. 20. pp. 5649-5652.

GOST all authors (up to 50) Copy

Liu Z. An Intermolecular Azidoheteroarylation of Simple Alkenes via Free-Radical Multicomponent Cascade Reactions // Organic Letters. 2017. Vol. 19. No. 20. pp. 5649-5652.

RIS |

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RIS Copy

TY - JOUR

DO - 10.1021/acs.orglett.7b02788

UR - https://doi.org/10.1021/acs.orglett.7b02788

TI - An Intermolecular Azidoheteroarylation of Simple Alkenes via Free-Radical Multicomponent Cascade Reactions

T2 - Organic Letters

AU - Liu, Zhongquan

PY - 2017

DA - 2017/09/29

PB - American Chemical Society (ACS)

SP - 5649-5652

IS - 20

VL - 19

PMID - 28961001

SN - 1523-7060

SN - 1523-7052

ER -

BibTex |

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BibTex (up to 50 authors) Copy

@article{2017_Liu,

author = {Zhongquan Liu},

title = {An Intermolecular Azidoheteroarylation of Simple Alkenes via Free-Radical Multicomponent Cascade Reactions},

journal = {Organic Letters},

year = {2017},

volume = {19},

publisher = {American Chemical Society (ACS)},

month = {sep},

url = {https://doi.org/10.1021/acs.orglett.7b02788},

number = {20},

pages = {5649--5652},

doi = {10.1021/acs.orglett.7b02788}

}

MLA

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MLA Copy

Liu, Zhongquan. “An Intermolecular Azidoheteroarylation of Simple Alkenes via Free-Radical Multicomponent Cascade Reactions.” Organic Letters, vol. 19, no. 20, Sep. 2017, pp. 5649-5652. https://doi.org/10.1021/acs.orglett.7b02788.

Publisher

American Chemical Society (ACS)

Journal

Organic Letters

scimago Q1

wos Q1

SJR

1.235

CiteScore

8.7

Impact factor

5.0

ISSN

15237060 (Print)

15237052 (Electronic)