Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor
Xiaoze Bao
1
,
SHIQIANG WEI
1
,
Xing-Kai Qian
2
,
Jingping Qu
1
,
Baomin Wang
1
,
Li Wei Zou
2
,
Guang-Bo Ge
2
Publication type: Journal Article
Publication date: 2018-05-22
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
29786435
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
A catalytic asymmetric [3 + 2] cyclization of novel 4-isothiocyanato pyrazolones and isatin-derived ketimines was developed, delivering a wide range of intriguing dispirotriheterocyclic products in high yield with excellent diastereoselectivity and enantioselectivity. A chiral sulfoxide derivative of this dispirocyclic product was identified to be a promising hit of the human carboxylesterase 1 inhibitor, and the significant difference of the activity between two enantiomers emphasized the importance of this asymmetric process.
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84
Total citations:
84
Citations from 2024:
10
(11%)
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BibTex |
MLA
Cite this
GOST
Copy
Bao X. et al. Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor // Organic Letters. 2018. Vol. 20. No. 11. pp. 3394-3398.
GOST all authors (up to 50)
Copy
Bao X., WEI S., Qian X., Qu J., Wang B., Zou L. W., Ge G. Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor // Organic Letters. 2018. Vol. 20. No. 11. pp. 3394-3398.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.orglett.8b01316
UR - https://doi.org/10.1021/acs.orglett.8b01316
TI - Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor
T2 - Organic Letters
AU - Bao, Xiaoze
AU - WEI, SHIQIANG
AU - Qian, Xing-Kai
AU - Qu, Jingping
AU - Wang, Baomin
AU - Zou, Li Wei
AU - Ge, Guang-Bo
PY - 2018
DA - 2018/05/22
PB - American Chemical Society (ACS)
SP - 3394-3398
IS - 11
VL - 20
PMID - 29786435
SN - 1523-7060
SN - 1523-7052
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Bao,
author = {Xiaoze Bao and SHIQIANG WEI and Xing-Kai Qian and Jingping Qu and Baomin Wang and Li Wei Zou and Guang-Bo Ge},
title = {Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor},
journal = {Organic Letters},
year = {2018},
volume = {20},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/acs.orglett.8b01316},
number = {11},
pages = {3394--3398},
doi = {10.1021/acs.orglett.8b01316}
}
Cite this
MLA
Copy
Bao, Xiaoze, et al. “Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor.” Organic Letters, vol. 20, no. 11, May. 2018, pp. 3394-3398. https://doi.org/10.1021/acs.orglett.8b01316.
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