Design and De Novo Synthesis of 6-Aza-artemisinins
Karunakar Reddy Bonepally
1
,
Takahisa Hiruma
2
,
Haruki Mizoguchi
2
,
Kyohei Ochiai
2
,
Shun SUZUKI
2
,
Hideaki Oikawa
2
,
Aki Ishiyama
3
,
Rei Hokari
3
,
Masato Iwatsuki
3
,
Kazuhiko Otoguro
3
,
Satoshi Omura
3
,
Hiroki Oguri
1
Publication type: Journal Article
Publication date: 2018-07-23
scimago Q1
wos Q1
SJR: 1.235
CiteScore: 8.7
Impact factor: 5.0
ISSN: 15237060, 15237052
PubMed ID:
30036066
Organic Chemistry
Biochemistry
Physical and Theoretical Chemistry
Abstract
Development of designer natural product variants, 6-aza-artemisinins, enabled us to achieve structural modification of the hitherto unexplored cyclohexane moiety of artemisinin and concise de novo synthesis of the tetracyclic scaffold in just four steps from the modular assembly of three simple building blocks. This expeditious catalytic asymmetric synthetic approach generated lead candidates exhibiting superior in vivo antimalarial activities to artemisinin.
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Metrics
17
Total citations:
17
Citations from 2024:
6
(35.3%)
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MLA
Cite this
GOST
Copy
Bonepally K. R. et al. Design and De Novo Synthesis of 6-Aza-artemisinins // Organic Letters. 2018. Vol. 20. No. 15. pp. 4667-4671.
GOST all authors (up to 50)
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Bonepally K. R., Hiruma T., Mizoguchi H., Ochiai K., SUZUKI S., Oikawa H., Ishiyama A., Hokari R., Iwatsuki M., Otoguro K., Omura S., Oguri H. Design and De Novo Synthesis of 6-Aza-artemisinins // Organic Letters. 2018. Vol. 20. No. 15. pp. 4667-4671.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acs.orglett.8b01987
UR - https://doi.org/10.1021/acs.orglett.8b01987
TI - Design and De Novo Synthesis of 6-Aza-artemisinins
T2 - Organic Letters
AU - Bonepally, Karunakar Reddy
AU - Hiruma, Takahisa
AU - Mizoguchi, Haruki
AU - Ochiai, Kyohei
AU - SUZUKI, Shun
AU - Oikawa, Hideaki
AU - Ishiyama, Aki
AU - Hokari, Rei
AU - Iwatsuki, Masato
AU - Otoguro, Kazuhiko
AU - Omura, Satoshi
AU - Oguri, Hiroki
PY - 2018
DA - 2018/07/23
PB - American Chemical Society (ACS)
SP - 4667-4671
IS - 15
VL - 20
PMID - 30036066
SN - 1523-7060
SN - 1523-7052
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2018_Bonepally,
author = {Karunakar Reddy Bonepally and Takahisa Hiruma and Haruki Mizoguchi and Kyohei Ochiai and Shun SUZUKI and Hideaki Oikawa and Aki Ishiyama and Rei Hokari and Masato Iwatsuki and Kazuhiko Otoguro and Satoshi Omura and Hiroki Oguri},
title = {Design and De Novo Synthesis of 6-Aza-artemisinins},
journal = {Organic Letters},
year = {2018},
volume = {20},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021/acs.orglett.8b01987},
number = {15},
pages = {4667--4671},
doi = {10.1021/acs.orglett.8b01987}
}
Cite this
MLA
Copy
Bonepally, Karunakar Reddy, et al. “Design and De Novo Synthesis of 6-Aza-artemisinins.” Organic Letters, vol. 20, no. 15, Jul. 2018, pp. 4667-4671. https://doi.org/10.1021/acs.orglett.8b01987.