ACS applied materials & interfaces, volume 13, issue 20, pages 23452-23468

Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens

Filippovich Svetlana Yu 2
Dyatlov Ivan A 3
Slukin Pavel V 3
Ignatov Sergei G. 3
Publication typeJournal Article
Publication date2021-05-17
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor9.5
ISSN19448244, 19448252
General Materials Science
Abstract
Utilization of antibacterial components-conjugated nanoparticles (NPs) is emerging as an attractive strategy for combating various pathogens. Herein, we demonstrate that Ag/BN NPs and antibiotic-loaded BN and Ag/BN nanoconjugates are promising carriers to fight bacterial and fungal infections. Extensive biological tests included two types of Gram-positive methicillin-resistant Staphylococcus aureus strains (B8469 and MW2), two types of Gram-negative Pseudomonas aeruginosa strains (ATCC27853 and B1307/17), and 47 types of Escherichia coli strains (including 41 multidrug-resistant ones), as well as five types of fungal cultures: Candida albicans (candidiasis-thrush) ATCC90028 and ATCC24433, Candida parapsilosis ATCC90018, Candida auris CBS109113, and Neurospora crassa wt. We have demonstrated that, even within a single genus Escherichia, there are many hospital E. coli strains with multi-drug resistance to different antibiotics. Gentamicin-loaded BN NPs have high bactericidal activity against S. aureus, P. aeruginosa, and 38 types of the E. coli strains. For the rest of the tested E. coli strains, the Ag nanoparticle-containing nanohybrids have shown superior bactericidal efficiency. The Ag/BN nanohybrids and amphotericin B-loaded BN and Ag/BN NPs also reveal high fungicidal activity against C. albicans, C. auris, C. parapsilosis, and N. crassa cells. In addition, based on the density functional theory calculations, the nature of antibiotic-nanoparticle interaction, the sorption capacity of the BN and Ag/BN nanohybrids for gentamicin and amphotericin B, and the most energetically favorable positions of the drug molecules relative to the carrier surface, which lead to lowest binding energies, have been determined. The obtained results clearly show high therapeutic potential of the antibiotic-loaded Ag/BN nanocarriers providing a broad bactericidal and fungicidal protection against all of the studied pathogens.

Citations by journals

1
2
Nanomaterials
Nanomaterials, 2, 12.5%
Nanomaterials
2 publications, 12.5%
ACS Applied Bio Materials
ACS Applied Bio Materials, 2, 12.5%
ACS Applied Bio Materials
2 publications, 12.5%
Applied Biochemistry and Microbiology
Applied Biochemistry and Microbiology, 2, 12.5%
Applied Biochemistry and Microbiology
2 publications, 12.5%
Ceramics International
Ceramics International, 1, 6.25%
Ceramics International
1 publication, 6.25%
Colloids and Surfaces A: Physicochemical and Engineering Aspects
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 1, 6.25%
Colloids and Surfaces A: Physicochemical and Engineering Aspects
1 publication, 6.25%
Materials Science and Engineering B: Solid-State Materials for Advanced Technology
Materials Science and Engineering B: Solid-State Materials for Advanced Technology, 1, 6.25%
Materials Science and Engineering B: Solid-State Materials for Advanced Technology
1 publication, 6.25%
Biomaterials Advances
Biomaterials Advances, 1, 6.25%
Biomaterials Advances
1 publication, 6.25%
Applied Surface Science
Applied Surface Science, 1, 6.25%
Applied Surface Science
1 publication, 6.25%
Colloids and Surfaces B: Biointerfaces
Colloids and Surfaces B: Biointerfaces, 1, 6.25%
Colloids and Surfaces B: Biointerfaces
1 publication, 6.25%
Materials Today Sustainability
Materials Today Sustainability, 1, 6.25%
Materials Today Sustainability
1 publication, 6.25%
Nanotechnology
Nanotechnology, 1, 6.25%
Nanotechnology
1 publication, 6.25%
Macromolecular Research, 1, 6.25%
Macromolecular Research
1 publication, 6.25%
Expert Opinion on Drug Delivery
Expert Opinion on Drug Delivery, 1, 6.25%
Expert Opinion on Drug Delivery
1 publication, 6.25%
1
2

Citations by publishers

1
2
3
4
5
6
7
Elsevier
Elsevier, 7, 43.75%
Elsevier
7 publications, 43.75%
Multidisciplinary Digital Publishing Institute (MDPI)
Multidisciplinary Digital Publishing Institute (MDPI), 2, 12.5%
Multidisciplinary Digital Publishing Institute (MDPI)
2 publications, 12.5%
American Chemical Society (ACS)
American Chemical Society (ACS), 2, 12.5%
American Chemical Society (ACS)
2 publications, 12.5%
Pleiades Publishing
Pleiades Publishing, 2, 12.5%
Pleiades Publishing
2 publications, 12.5%
IOP Publishing
IOP Publishing, 1, 6.25%
IOP Publishing
1 publication, 6.25%
Polymer Society of Korea, 1, 6.25%
Polymer Society of Korea
1 publication, 6.25%
Taylor & Francis
Taylor & Francis, 1, 6.25%
Taylor & Francis
1 publication, 6.25%
1
2
3
4
5
6
7
  • We do not take into account publications that without a DOI.
  • Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
  • Statistics recalculated weekly.
Metrics
Share
Cite this
GOST |
Cite this
GOST Copy
Kotyakova K. Yu. et al. Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens // ACS applied materials & interfaces. 2021. Vol. 13. No. 20. pp. 23452-23468.
GOST all authors (up to 50) Copy
Kotyakova K. Yu., Antipina L. Yu., Permyakova E. S., Kovalskii A. M., Konopatsky A., Filippovich S. Yu., Dyatlov I. A., Slukin P. V., Ignatov S. G., Shtansky D. V. Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens // ACS applied materials & interfaces. 2021. Vol. 13. No. 20. pp. 23452-23468.
RIS |
Cite this
RIS Copy
TY - JOUR
DO - 10.1021/acsami.1c03775
UR - https://doi.org/10.1021%2Facsami.1c03775
TI - Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens
T2 - ACS applied materials & interfaces
AU - Filippovich, Svetlana Yu
AU - Slukin, Pavel V
AU - Ignatov, Sergei G.
AU - Permyakova, Elizaveta S
AU - Kovalskii, A. M.
AU - Shtansky, Dmitry V.
AU - Kotyakova, Kristina Yu
AU - Antipina, Liubov Yu
AU - Konopatsky, Anton
AU - Dyatlov, Ivan A
PY - 2021
DA - 2021/05/17 00:00:00
PB - American Chemical Society (ACS)
SP - 23452-23468
IS - 20
VL - 13
SN - 1944-8244
SN - 1944-8252
ER -
BibTex |
Cite this
BibTex Copy
@article{2021_Kotyakova
author = {Svetlana Yu Filippovich and Pavel V Slukin and Sergei G. Ignatov and Elizaveta S Permyakova and A. M. Kovalskii and Dmitry V. Shtansky and Kristina Yu Kotyakova and Liubov Yu Antipina and Anton Konopatsky and Ivan A Dyatlov},
title = {Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens},
journal = {ACS applied materials & interfaces},
year = {2021},
volume = {13},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021%2Facsami.1c03775},
number = {20},
pages = {23452--23468},
doi = {10.1021/acsami.1c03775}
}
MLA
Cite this
MLA Copy
Kotyakova, Kristina Yu., et al. “Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens.” ACS applied materials & interfaces, vol. 13, no. 20, May. 2021, pp. 23452-23468. https://doi.org/10.1021%2Facsami.1c03775.
Found error?