ACS applied materials & interfaces, volume 13, issue 20, pages 23452-23468
Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens
Kovalskii A. M.
1
,
Konopatsky Anton
1
,
Filippovich Svetlana Yu
2
,
Dyatlov Ivan A
3
,
Slukin Pavel V
3
,
Ignatov Sergei G.
3
,
Publication type: Journal Article
Publication date: 2021-05-17
Journal:
ACS applied materials & interfaces
Quartile SCImago
Q1
Quartile WOS
Q1
Impact factor: 9.5
ISSN: 19448244, 19448252
General Materials Science
Abstract
Utilization of antibacterial components-conjugated nanoparticles (NPs) is emerging as an attractive strategy for combating various pathogens. Herein, we demonstrate that Ag/BN NPs and antibiotic-loaded BN and Ag/BN nanoconjugates are promising carriers to fight bacterial and fungal infections. Extensive biological tests included two types of Gram-positive methicillin-resistant Staphylococcus aureus strains (B8469 and MW2), two types of Gram-negative Pseudomonas aeruginosa strains (ATCC27853 and B1307/17), and 47 types of Escherichia coli strains (including 41 multidrug-resistant ones), as well as five types of fungal cultures: Candida albicans (candidiasis-thrush) ATCC90028 and ATCC24433, Candida parapsilosis ATCC90018, Candida auris CBS109113, and Neurospora crassa wt. We have demonstrated that, even within a single genus Escherichia, there are many hospital E. coli strains with multi-drug resistance to different antibiotics. Gentamicin-loaded BN NPs have high bactericidal activity against S. aureus, P. aeruginosa, and 38 types of the E. coli strains. For the rest of the tested E. coli strains, the Ag nanoparticle-containing nanohybrids have shown superior bactericidal efficiency. The Ag/BN nanohybrids and amphotericin B-loaded BN and Ag/BN NPs also reveal high fungicidal activity against C. albicans, C. auris, C. parapsilosis, and N. crassa cells. In addition, based on the density functional theory calculations, the nature of antibiotic-nanoparticle interaction, the sorption capacity of the BN and Ag/BN nanohybrids for gentamicin and amphotericin B, and the most energetically favorable positions of the drug molecules relative to the carrier surface, which lead to lowest binding energies, have been determined. The obtained results clearly show high therapeutic potential of the antibiotic-loaded Ag/BN nanocarriers providing a broad bactericidal and fungicidal protection against all of the studied pathogens.
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1 publication, 6.25%
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1 publication, 6.25%
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1 publication, 6.25%
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1 publication, 6.25%
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1 publication, 6.25%
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1 publication, 6.25%
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1 publication, 6.25%
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1 publication, 6.25%
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1
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Citations by publishers
1
2
3
4
5
6
7
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Elsevier
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7 publications, 43.75%
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2 publications, 12.5%
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2 publications, 12.5%
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Pleiades Publishing
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Pleiades Publishing
2 publications, 12.5%
|
IOP Publishing
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IOP Publishing
1 publication, 6.25%
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Polymer Society of Korea
|
Polymer Society of Korea, 1, 6.25%
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1 publication, 6.25%
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Taylor & Francis
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Taylor & Francis
1 publication, 6.25%
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1
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3
4
5
6
7
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- We do not take into account publications that without a DOI.
- Statistics recalculated only for publications connected to researchers, organizations and labs registered on the platform.
- Statistics recalculated weekly.
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Kotyakova K. Yu. et al. Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens // ACS applied materials & interfaces. 2021. Vol. 13. No. 20. pp. 23452-23468.
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Kotyakova K. Yu., Antipina L. Yu., Permyakova E. S., Kovalskii A. M., Konopatsky A., Filippovich S. Yu., Dyatlov I. A., Slukin P. V., Ignatov S. G., Shtansky D. V. Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens // ACS applied materials & interfaces. 2021. Vol. 13. No. 20. pp. 23452-23468.
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TY - JOUR
DO - 10.1021/acsami.1c03775
UR - https://doi.org/10.1021%2Facsami.1c03775
TI - Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens
T2 - ACS applied materials & interfaces
AU - Filippovich, Svetlana Yu
AU - Slukin, Pavel V
AU - Ignatov, Sergei G.
AU - Permyakova, Elizaveta S
AU - Kovalskii, A. M.
AU - Shtansky, Dmitry V.
AU - Kotyakova, Kristina Yu
AU - Antipina, Liubov Yu
AU - Konopatsky, Anton
AU - Dyatlov, Ivan A
PY - 2021
DA - 2021/05/17 00:00:00
PB - American Chemical Society (ACS)
SP - 23452-23468
IS - 20
VL - 13
SN - 1944-8244
SN - 1944-8252
ER -
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@article{2021_Kotyakova
author = {Svetlana Yu Filippovich and Pavel V Slukin and Sergei G. Ignatov and Elizaveta S Permyakova and A. M. Kovalskii and Dmitry V. Shtansky and Kristina Yu Kotyakova and Liubov Yu Antipina and Anton Konopatsky and Ivan A Dyatlov},
title = {Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens},
journal = {ACS applied materials & interfaces},
year = {2021},
volume = {13},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021%2Facsami.1c03775},
number = {20},
pages = {23452--23468},
doi = {10.1021/acsami.1c03775}
}
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MLA
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Kotyakova, Kristina Yu., et al. “Ag-Doped and Antibiotic-Loaded Hexagonal Boron Nitride Nanoparticles as Promising Carriers to Fight Different Pathogens.” ACS applied materials & interfaces, vol. 13, no. 20, May. 2021, pp. 23452-23468. https://doi.org/10.1021%2Facsami.1c03775.