Photoinduced Reduction of Novel Dual-Action Riboplatin Pt(IV) Prodrug
Olga O. Krasnovskaya
1, 2
,
Roman A. Akasov
3, 4
,
Daniil V. Spector
1, 2
,
Kirill G. Pavlov
1
,
Anna A. Bubley
1
,
Vladimir A. Kuzmin
5
,
Alexey A. Kostyukov
5
,
Evgeny V. Khaydukov
3, 4
,
Elena V. Lopatukhina
1
,
Alevtina S. Semkina
6, 7
,
Kseniya Yu. Vlasova
1, 6
,
Sergey A. Sypalov
8
,
S.A. Sypalov
8
,
Alexander S. Erofeev
1, 2
,
Alexander V. Erofeev
1, 2
,
Petr V. Gorelkin
1, 2
,
Alexander N. Vaneev
1, 2
,
Vita N Nikitina
1
,
Daria A. Ipatova
1
,
Dmitrii M. Mazur
1
,
Nikolay V. Zyk
1
,
Dmitry A. Sakharov
9
,
1
2
6
8
Publication type: Journal Article
Publication date: 2023-02-28
scimago Q1
wos Q1
SJR: 1.921
CiteScore: 14.5
Impact factor: 8.2
ISSN: 19448244, 19448252
PubMed ID:
36854172
General Materials Science
Abstract
Controlled photoreduction of Pt(IV) prodrugs is a challenging task due to the possibility of targeted light-controlled activation of anticancer agents without affecting healthy tissues. Also, a conjugation of photosensitizers and clinically used platinum drugs into one Pt(IV) prodrug allows combining photodynamic therapy and chemotherapy approaches into one molecule. Herein, we designed the cisplatin-based Pt(IV) prodrug Riboplatin with tetraacetylriboflavin in the axial position. A novel Pt(IV) prodrug is able to act both as a photodynamic therapy (PDT) agent through the conversion of ground-state 3O2 to excited-state 1O2 and as an agent of photoactivated chemotherapy (PACT) through releasing of cisplatin under gentle blue light irradiation, without the requirement of a reducing agent. The light-induced behavior of Riboplatin was investigated using an electrochemical sensor in MCF-7 tumor spheroids. Photocontrolled cisplatin release and ROS generation were detected electrochemically in real time. This appears to be the first confirmation of simultaneous photoactivated release of anticancer drug cisplatin and ROS from a dual-action Pt(IV) prodrug observed from the inside of living tumor spheroids.
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Metrics
30
Total citations:
30
Citations from 2025:
10
(33.33%)
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MLA
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GOST
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Krasnovskaya O. O. et al. Photoinduced Reduction of Novel Dual-Action Riboplatin Pt(IV) Prodrug // ACS applied materials & interfaces. 2023. Vol. 15. No. 10. pp. 12882-12894.
GOST all authors (up to 50)
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Krasnovskaya O. O., Akasov R. A., Spector D. V., Pavlov K. G., Bubley A. A., Kuzmin V. A., Kuzmin V. L., Kostyukov A. A., Khaydukov E. V., Lopatukhina E. V., Semkina A. S., Vlasova K. Y., Sypalov S. A., Sypalov S., Erofeev A. S., Erofeev A. V., Gorelkin P. V., Vaneev A. N., Nikitina V. N., Skvortsov D. A., Ipatova D. A., Mazur D. M., Zyk N. V., Sakharov D. A., Majouga A. G., Beloglazkina E. K. Photoinduced Reduction of Novel Dual-Action Riboplatin Pt(IV) Prodrug // ACS applied materials & interfaces. 2023. Vol. 15. No. 10. pp. 12882-12894.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acsami.3c01771
UR - https://pubs.acs.org/doi/10.1021/acsami.3c01771
TI - Photoinduced Reduction of Novel Dual-Action Riboplatin Pt(IV) Prodrug
T2 - ACS applied materials & interfaces
AU - Krasnovskaya, Olga O.
AU - Akasov, Roman A.
AU - Spector, Daniil V.
AU - Pavlov, Kirill G.
AU - Bubley, Anna A.
AU - Kuzmin, Vladimir A.
AU - Kuzmin, Vladimir L.
AU - Kostyukov, Alexey A.
AU - Khaydukov, Evgeny V.
AU - Lopatukhina, Elena V.
AU - Semkina, Alevtina S.
AU - Vlasova, Kseniya Yu.
AU - Sypalov, Sergey A.
AU - Sypalov, S.A.
AU - Erofeev, Alexander S.
AU - Erofeev, Alexander V.
AU - Gorelkin, Petr V.
AU - Vaneev, Alexander N.
AU - Nikitina, Vita N
AU - Skvortsov, Dmitrii A.
AU - Ipatova, Daria A.
AU - Mazur, Dmitrii M.
AU - Zyk, Nikolay V.
AU - Sakharov, Dmitry A.
AU - Majouga, Alexander G.
AU - Beloglazkina, Elena K.
PY - 2023
DA - 2023/02/28
PB - American Chemical Society (ACS)
SP - 12882-12894
IS - 10
VL - 15
PMID - 36854172
SN - 1944-8244
SN - 1944-8252
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2023_Krasnovskaya,
author = {Olga O. Krasnovskaya and Roman A. Akasov and Daniil V. Spector and Kirill G. Pavlov and Anna A. Bubley and Vladimir A. Kuzmin and Vladimir L. Kuzmin and Alexey A. Kostyukov and Evgeny V. Khaydukov and Elena V. Lopatukhina and Alevtina S. Semkina and Kseniya Yu. Vlasova and Sergey A. Sypalov and S.A. Sypalov and Alexander S. Erofeev and Alexander V. Erofeev and Petr V. Gorelkin and Alexander N. Vaneev and Vita N Nikitina and Dmitrii A. Skvortsov and Daria A. Ipatova and Dmitrii M. Mazur and Nikolay V. Zyk and Dmitry A. Sakharov and Alexander G. Majouga and Elena K. Beloglazkina},
title = {Photoinduced Reduction of Novel Dual-Action Riboplatin Pt(IV) Prodrug},
journal = {ACS applied materials & interfaces},
year = {2023},
volume = {15},
publisher = {American Chemical Society (ACS)},
month = {feb},
url = {https://pubs.acs.org/doi/10.1021/acsami.3c01771},
number = {10},
pages = {12882--12894},
doi = {10.1021/acsami.3c01771}
}
Cite this
MLA
Copy
Krasnovskaya, Olga O., et al. “Photoinduced Reduction of Novel Dual-Action Riboplatin Pt(IV) Prodrug.” ACS applied materials & interfaces, vol. 15, no. 10, Feb. 2023, pp. 12882-12894. https://pubs.acs.org/doi/10.1021/acsami.3c01771.