Ultrasonically Assisted Polysaccharide Microcontainers for Delivery of Lipophilic Antitumor Drugs: Preparation and in Vitro Evaluation.
Roman A. Akasov
1, 2
,
Tatiana Borodina
2
,
Ekaterina Zaytseva
1
,
Anastasia Sumina
1
,
Tatiana Bukreeva
2, 3
,
Sergey Burov
4
,
E. Markvicheva
1
Тип публикации: Journal Article
Дата публикации: 2015-07-22
scimago Q1
wos Q1
БС1
SJR: 1.921
CiteScore: 14.5
Impact factor: 8.2
ISSN: 19448244, 19448252
PubMed ID:
26158302
General Materials Science
Краткое описание
High toxicity, poor selectivity, and severe side effects are major drawbacks of anticancer drugs. Various drug delivery systems could be proposed to overcome these limitations. The aim of this study was to fabricate polysaccharide microcontainers (MCs) loaded with thymoquinone (TQ) by a one-step ultrasonication technique and to study their cellular uptake and cytotoxicity in vitro. Two MC fractions with a mean size of 500 nm (MC-0.5) and 2 μM (MC-2) were prepared and characterized. Uptake of the MCs by mouse melanoma M-3 cells was evaluated in both 2D (monolayer culture) and 3D (multicellular tumor spheroids) models by confocal microscopy, flow cytometry, and fluorimetry. The higher cytotoxicity of the TQ-MC-0.5 sample than the TQ-MC-2 fraction was in good correlation with higher MC-0.5 accumulation in the cells. The MC-0.5 beads were more promising than the MC-2 particles because of a higher cellular uptake in both 2D and 3D models, an enhanced antitumor effect, and a lower nonspecific toxicity.
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Akasov R. A. et al. Ultrasonically Assisted Polysaccharide Microcontainers for Delivery of Lipophilic Antitumor Drugs: Preparation and in Vitro Evaluation. // ACS applied materials & interfaces. 2015. Vol. 7. No. 30. pp. 16581-16589.
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Akasov R. A., Borodina T., Zaytseva E., Sumina A., Bukreeva T., Burov S., Markvicheva E. Ultrasonically Assisted Polysaccharide Microcontainers for Delivery of Lipophilic Antitumor Drugs: Preparation and in Vitro Evaluation. // ACS applied materials & interfaces. 2015. Vol. 7. No. 30. pp. 16581-16589.
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TY - JOUR
DO - 10.1021/acsami.5b04141
UR - https://doi.org/10.1021/acsami.5b04141
TI - Ultrasonically Assisted Polysaccharide Microcontainers for Delivery of Lipophilic Antitumor Drugs: Preparation and in Vitro Evaluation.
T2 - ACS applied materials & interfaces
AU - Akasov, Roman A.
AU - Borodina, Tatiana
AU - Zaytseva, Ekaterina
AU - Sumina, Anastasia
AU - Bukreeva, Tatiana
AU - Burov, Sergey
AU - Markvicheva, E.
PY - 2015
DA - 2015/07/22
PB - American Chemical Society (ACS)
SP - 16581-16589
IS - 30
VL - 7
PMID - 26158302
SN - 1944-8244
SN - 1944-8252
ER -
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@article{2015_Akasov,
author = {Roman A. Akasov and Tatiana Borodina and Ekaterina Zaytseva and Anastasia Sumina and Tatiana Bukreeva and Sergey Burov and E. Markvicheva},
title = {Ultrasonically Assisted Polysaccharide Microcontainers for Delivery of Lipophilic Antitumor Drugs: Preparation and in Vitro Evaluation.},
journal = {ACS applied materials & interfaces},
year = {2015},
volume = {7},
publisher = {American Chemical Society (ACS)},
month = {jul},
url = {https://doi.org/10.1021/acsami.5b04141},
number = {30},
pages = {16581--16589},
doi = {10.1021/acsami.5b04141}
}
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MLA
Скопировать
Akasov, Roman A., et al. “Ultrasonically Assisted Polysaccharide Microcontainers for Delivery of Lipophilic Antitumor Drugs: Preparation and in Vitro Evaluation..” ACS applied materials & interfaces, vol. 7, no. 30, Jul. 2015, pp. 16581-16589. https://doi.org/10.1021/acsami.5b04141.
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