Virus-Inspired Self-Assembled Nanofibers with Aggregation-Induced Emission for Highly Efficient and Visible Gene Delivery.
Chunqiu Zhang
1
,
Tingbin Zhang
2
,
Shubin Jin
1
,
XiangDong Xue
1
,
Xiaolong Yang
1
,
Ningqiang Gong
1
,
Jinchao Zhang
3
,
Paul C. Wang
4, 5
,
Jianhua Tian
2
,
Jinfeng Xing
2
,
Xing Jie Liang
1
Publication type: Journal Article
Publication date: 2017-01-24
scimago Q1
wos Q1
SJR: 1.921
CiteScore: 14.5
Impact factor: 8.2
ISSN: 19448244, 19448252
PubMed ID:
28074644
General Materials Science
Abstract
High-efficiency gene transfer and suitably low cytotoxicity are the main goals of gene transfection systems based on nonviral vectors. In addition, it is desirable to track the gene transfer process in order to observe and explain the mechanism. Herein, inspired by viral structures that are optimized for gene delivery, we designed a small-molecule gene vector (TR4) with aggregation-induced emission properties by capping a peptide containing four arginine residues with tetraphenylethene (TPE) and a lipophilic tail. This novel vector can self-assemble with plasmid DNA to form nanofibers in solution with low cytotoxicity, high stability, and high transfection efficiency. pDNA@TR4 complexes were able to transfect a variety of different cell lines, including stem cells. The self-assembly process induces bright fluorescence from TPE, which makes the nanofibers visible by confocal laser scanning microscopy (CLSM). This allows us for the tracking of the gene delivery process.
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Metrics
45
Total citations:
45
Citations from 2024:
5
(11%)
Cite this
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MLA
Cite this
GOST
Copy
Zhang C. et al. Virus-Inspired Self-Assembled Nanofibers with Aggregation-Induced Emission for Highly Efficient and Visible Gene Delivery. // ACS applied materials & interfaces. 2017. Vol. 9. No. 5. pp. 4425-4432.
GOST all authors (up to 50)
Copy
Zhang C., Zhang T., Jin S., Xue X., Yang X., Gong N., Zhang J., Wang P. C., Tian J., Xing J., Liang X. J. Virus-Inspired Self-Assembled Nanofibers with Aggregation-Induced Emission for Highly Efficient and Visible Gene Delivery. // ACS applied materials & interfaces. 2017. Vol. 9. No. 5. pp. 4425-4432.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acsami.6b11536
UR - https://doi.org/10.1021/acsami.6b11536
TI - Virus-Inspired Self-Assembled Nanofibers with Aggregation-Induced Emission for Highly Efficient and Visible Gene Delivery.
T2 - ACS applied materials & interfaces
AU - Zhang, Chunqiu
AU - Zhang, Tingbin
AU - Jin, Shubin
AU - Xue, XiangDong
AU - Yang, Xiaolong
AU - Gong, Ningqiang
AU - Zhang, Jinchao
AU - Wang, Paul C.
AU - Tian, Jianhua
AU - Xing, Jinfeng
AU - Liang, Xing Jie
PY - 2017
DA - 2017/01/24
PB - American Chemical Society (ACS)
SP - 4425-4432
IS - 5
VL - 9
PMID - 28074644
SN - 1944-8244
SN - 1944-8252
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Zhang,
author = {Chunqiu Zhang and Tingbin Zhang and Shubin Jin and XiangDong Xue and Xiaolong Yang and Ningqiang Gong and Jinchao Zhang and Paul C. Wang and Jianhua Tian and Jinfeng Xing and Xing Jie Liang},
title = {Virus-Inspired Self-Assembled Nanofibers with Aggregation-Induced Emission for Highly Efficient and Visible Gene Delivery.},
journal = {ACS applied materials & interfaces},
year = {2017},
volume = {9},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/acsami.6b11536},
number = {5},
pages = {4425--4432},
doi = {10.1021/acsami.6b11536}
}
Cite this
MLA
Copy
Zhang, Chunqiu, et al. “Virus-Inspired Self-Assembled Nanofibers with Aggregation-Induced Emission for Highly Efficient and Visible Gene Delivery..” ACS applied materials & interfaces, vol. 9, no. 5, Jan. 2017, pp. 4425-4432. https://doi.org/10.1021/acsami.6b11536.
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