Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations
Тип публикации: Journal Article
Дата публикации: 2017-12-26
scimago Q1
wos Q2
БС1
SJR: 1.383
CiteScore: 7.1
Impact factor: 3.8
ISSN: 15548929, 15548937
PubMed ID:
29202222
Biochemistry
General Medicine
Molecular Medicine
Краткое описание
Pan-Assay Interference Compounds (PAINS) are very familiar to medicinal chemists who have spent time fruitlessly trying to optimize these nonprogressible compounds. Electronic filters formulated to recognize PAINS can process hundreds and thousands of compounds in seconds and are in widespread current use to identify PAINS in order to exclude them from further analysis. However, this practice is fraught with danger because such black box treatment is simplistic. Here, we outline for the first time all necessary considerations for the appropriate use of PAINS filters.
Найдено
Ничего не найдено, попробуйте изменить настройки фильтра.
Для доступа к списку цитирований публикации необходимо авторизоваться.
Для доступа к списку профилей, цитирующих публикацию, необходимо авторизоваться.
Топ-30
Журналы
|
5
10
15
20
25
30
35
40
45
50
|
|
|
Journal of Medicinal Chemistry
48 публикаций, 8.28%
|
|
|
Journal of Chemical Information and Modeling
18 публикаций, 3.1%
|
|
|
European Journal of Medicinal Chemistry
14 публикаций, 2.41%
|
|
|
Molecules
14 публикаций, 2.41%
|
|
|
SLAS Discovery
14 публикаций, 2.41%
|
|
|
ChemMedChem
12 публикаций, 2.07%
|
|
|
Pharmaceuticals
11 публикаций, 1.9%
|
|
|
Scientific Reports
11 публикаций, 1.9%
|
|
|
RSC Medicinal Chemistry
11 публикаций, 1.9%
|
|
|
Molecular Diversity
10 публикаций, 1.72%
|
|
|
Bioorganic and Medicinal Chemistry
10 публикаций, 1.72%
|
|
|
Bioorganic Chemistry
10 публикаций, 1.72%
|
|
|
ACS Omega
8 публикаций, 1.38%
|
|
|
ACS Chemical Biology
7 публикаций, 1.21%
|
|
|
ACS Medicinal Chemistry Letters
7 публикаций, 1.21%
|
|
|
Journal of Biomolecular Structure and Dynamics
7 публикаций, 1.21%
|
|
|
Future Medicinal Chemistry
6 публикаций, 1.03%
|
|
|
Frontiers in Chemistry
6 публикаций, 1.03%
|
|
|
Frontiers in Pharmacology
6 публикаций, 1.03%
|
|
|
RSC Chemical Biology
6 публикаций, 1.03%
|
|
|
ACS Infectious Diseases
6 публикаций, 1.03%
|
|
|
Methods in Enzymology
6 публикаций, 1.03%
|
|
|
International Journal of Molecular Sciences
5 публикаций, 0.86%
|
|
|
Angewandte Chemie
5 публикаций, 0.86%
|
|
|
Angewandte Chemie - International Edition
5 публикаций, 0.86%
|
|
|
Expert Opinion on Drug Discovery
5 публикаций, 0.86%
|
|
|
eLife
5 публикаций, 0.86%
|
|
|
Journal of Biological Chemistry
4 публикации, 0.69%
|
|
|
ACS Chemical Neuroscience
4 публикации, 0.69%
|
|
|
5
10
15
20
25
30
35
40
45
50
|
Издатели
|
20
40
60
80
100
120
|
|
|
American Chemical Society (ACS)
116 публикаций, 20%
|
|
|
Elsevier
107 публикаций, 18.45%
|
|
|
Springer Nature
68 публикаций, 11.72%
|
|
|
Wiley
66 публикаций, 11.38%
|
|
|
MDPI
48 публикаций, 8.28%
|
|
|
Royal Society of Chemistry (RSC)
35 публикаций, 6.03%
|
|
|
Taylor & Francis
25 публикаций, 4.31%
|
|
|
Cold Spring Harbor Laboratory
22 публикации, 3.79%
|
|
|
Frontiers Media S.A.
20 публикаций, 3.45%
|
|
|
SAGE
12 публикаций, 2.07%
|
|
|
Bentham Science Publishers Ltd.
6 публикаций, 1.03%
|
|
|
Oxford University Press
6 публикаций, 1.03%
|
|
|
Public Library of Science (PLoS)
5 публикаций, 0.86%
|
|
|
eLife Sciences Publications
5 публикаций, 0.86%
|
|
|
Georg Thieme Verlag KG
4 публикации, 0.69%
|
|
|
American Society for Biochemistry and Molecular Biology
4 публикации, 0.69%
|
|
|
American Society for Microbiology
3 публикации, 0.52%
|
|
|
Portland Press
2 публикации, 0.34%
|
|
|
Hindawi Limited
2 публикации, 0.34%
|
|
|
American Association for Cancer Research (AACR)
2 публикации, 0.34%
|
|
|
Beilstein-Institut
1 публикация, 0.17%
|
|
|
Mary Ann Liebert
1 публикация, 0.17%
|
|
|
OOO Zhurnal "Mendeleevskie Soobshcheniya"
1 публикация, 0.17%
|
|
|
Federation of American Societies for Experimental Biology (FASEB)
1 публикация, 0.17%
|
|
|
Vojenska Lekarska Akademie
1 публикация, 0.17%
|
|
|
American Association for the Advancement of Science (AAAS)
1 публикация, 0.17%
|
|
|
Institute of Molecular Biology and Genetics (NAS Ukraine)
1 публикация, 0.17%
|
|
|
Annual Reviews
1 публикация, 0.17%
|
|
|
International Union of Crystallography (IUCr)
1 публикация, 0.17%
|
|
|
20
40
60
80
100
120
|
- Мы не учитываем публикации, у которых нет DOI.
- Статистика публикаций обновляется еженедельно.
Вы ученый?
Создайте профиль, чтобы получать персональные рекомендации коллег, конференций и новых статей.
Метрики
580
Всего цитирований:
580
Цитирований c 2025:
90
(15.52%)
Цитировать
ГОСТ |
RIS |
BibTex |
MLA
Цитировать
ГОСТ
Скопировать
Baell J. B., Nissink J. W. M. Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations // ACS Chemical Biology. 2017. Vol. 13. No. 1. pp. 36-44.
ГОСТ со всеми авторами (до 50)
Скопировать
Baell J. B., Nissink J. W. M. Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations // ACS Chemical Biology. 2017. Vol. 13. No. 1. pp. 36-44.
Цитировать
RIS
Скопировать
TY - JOUR
DO - 10.1021/acschembio.7b00903
UR - https://doi.org/10.1021/acschembio.7b00903
TI - Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations
T2 - ACS Chemical Biology
AU - Baell, Jonathan B.
AU - Nissink, J. Willem M.
PY - 2017
DA - 2017/12/26
PB - American Chemical Society (ACS)
SP - 36-44
IS - 1
VL - 13
PMID - 29202222
SN - 1554-8929
SN - 1554-8937
ER -
Цитировать
BibTex (до 50 авторов)
Скопировать
@article{2017_Baell,
author = {Jonathan B. Baell and J. Willem M. Nissink},
title = {Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations},
journal = {ACS Chemical Biology},
year = {2017},
volume = {13},
publisher = {American Chemical Society (ACS)},
month = {dec},
url = {https://doi.org/10.1021/acschembio.7b00903},
number = {1},
pages = {36--44},
doi = {10.1021/acschembio.7b00903}
}
Цитировать
MLA
Скопировать
Baell, Jonathan B., et al. “Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations.” ACS Chemical Biology, vol. 13, no. 1, Dec. 2017, pp. 36-44. https://doi.org/10.1021/acschembio.7b00903.