Biosynthesis and Chemical Applications of Thioamides
5
Carl R. Woese Institute for Genomic Biology
Publication type: Journal Article
Publication date: 2019-01-30
scimago Q1
wos Q2
SJR: 1.383
CiteScore: 7.1
Impact factor: 3.8
ISSN: 15548929, 15548937
PubMed ID:
30698414
Biochemistry
General Medicine
Molecular Medicine
Abstract
Thioamidation as a posttranslational modification is exceptionally rare, with only a few reported natural products and exactly one known protein example (methyl-coenzyme M reductase from methane-metabolizing archaea). Recently, there has been significant progress in elucidating the biosynthesis and function of several thioamide-containing natural compounds. Separate developments in the chemical installation of thioamides into peptides and proteins have enabled cell biology and biophysical studies to advance the current understanding of natural thioamides. This review highlights the various strategies used by Nature to install thioamides in peptidic scaffolds and the potential functions of this rare but important modification. We also discuss synthetic methods used for the site-selective incorporation of thioamides into polypeptides with a brief discussion of the physicochemical implications. This account will serve as a foundation for the further study of thioamides in natural products and their various applications.
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185
Total citations:
185
Citations from 2024:
65
(35.32%)
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GOST
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Mahanta N. et al. Biosynthesis and Chemical Applications of Thioamides // ACS Chemical Biology. 2019. Vol. 14. No. 2. pp. 142-163.
GOST all authors (up to 50)
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Mahanta N., Szantai Kis D. M., Petersson E., MITCHELL D. K. Biosynthesis and Chemical Applications of Thioamides // ACS Chemical Biology. 2019. Vol. 14. No. 2. pp. 142-163.
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RIS
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TY - JOUR
DO - 10.1021/acschembio.8b01022
UR - https://doi.org/10.1021/acschembio.8b01022
TI - Biosynthesis and Chemical Applications of Thioamides
T2 - ACS Chemical Biology
AU - Mahanta, Nilkamal
AU - Szantai Kis, D Miklos
AU - Petersson, Eva
AU - MITCHELL, DOUGLAS K.
PY - 2019
DA - 2019/01/30
PB - American Chemical Society (ACS)
SP - 142-163
IS - 2
VL - 14
PMID - 30698414
SN - 1554-8929
SN - 1554-8937
ER -
Cite this
BibTex (up to 50 authors)
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@article{2019_Mahanta,
author = {Nilkamal Mahanta and D Miklos Szantai Kis and Eva Petersson and DOUGLAS K. MITCHELL},
title = {Biosynthesis and Chemical Applications of Thioamides},
journal = {ACS Chemical Biology},
year = {2019},
volume = {14},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://doi.org/10.1021/acschembio.8b01022},
number = {2},
pages = {142--163},
doi = {10.1021/acschembio.8b01022}
}
Cite this
MLA
Copy
Mahanta, Nilkamal, et al. “Biosynthesis and Chemical Applications of Thioamides.” ACS Chemical Biology, vol. 14, no. 2, Jan. 2019, pp. 142-163. https://doi.org/10.1021/acschembio.8b01022.