Practical High-Throughput Experimentation for Chemists
1
Department of Process Research & Development, Merck & Co., Inc., 126 East Lincoln Avenue, Rahway, New Jersey 07065, United States
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Publication type: Journal Article
Publication date: 2017-05-26
scimago Q1
wos Q2
SJR: 0.805
CiteScore: 5.8
Impact factor: 4.0
ISSN: 19485875
PubMed ID:
28626518
Organic Chemistry
Drug Discovery
Biochemistry
Abstract
Large arrays of hypothesis-driven, rationally designed experiments are powerful tools for solving complex chemical problems. Conceptual and practical aspects of chemical high-throughput experimentation are discussed. A case study in the application of high-throughput experimentation to a key synthetic step in a drug discovery program and subsequent optimization for the first large scale synthesis of a drug candidate is exemplified.
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Metrics
292
Total citations:
292
Citations from 2024:
89
(30%)
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GOST
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Shevlin M. Practical High-Throughput Experimentation for Chemists // ACS Medicinal Chemistry Letters. 2017. Vol. 8. No. 6. pp. 601-607.
GOST all authors (up to 50)
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Shevlin M. Practical High-Throughput Experimentation for Chemists // ACS Medicinal Chemistry Letters. 2017. Vol. 8. No. 6. pp. 601-607.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/acsmedchemlett.7b00165
UR - https://doi.org/10.1021/acsmedchemlett.7b00165
TI - Practical High-Throughput Experimentation for Chemists
T2 - ACS Medicinal Chemistry Letters
AU - Shevlin, Michael
PY - 2017
DA - 2017/05/26
PB - American Chemical Society (ACS)
SP - 601-607
IS - 6
VL - 8
PMID - 28626518
SN - 1948-5875
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2017_Shevlin,
author = {Michael Shevlin},
title = {Practical High-Throughput Experimentation for Chemists},
journal = {ACS Medicinal Chemistry Letters},
year = {2017},
volume = {8},
publisher = {American Chemical Society (ACS)},
month = {may},
url = {https://doi.org/10.1021/acsmedchemlett.7b00165},
number = {6},
pages = {601--607},
doi = {10.1021/acsmedchemlett.7b00165}
}
Cite this
MLA
Copy
Shevlin, Michael. “Practical High-Throughput Experimentation for Chemists.” ACS Medicinal Chemistry Letters, vol. 8, no. 6, May. 2017, pp. 601-607. https://doi.org/10.1021/acsmedchemlett.7b00165.
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