ACS Nano, volume 9, issue 12, pages 12255-12263
Real-Time Monitoring Surface Chemistry-Dependent In Vivo Behaviors of Protein Nanocages via Encapsulating an NIR-II Ag2S Quantum Dot
2
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China
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3
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
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Publication type: Journal Article
Publication date: 2015-10-28
General Physics and Astronomy
General Materials Science
General Engineering
Abstract
Protein nanocages (PNCs) have been recognized as a promising platform for nanomedicine innovation. Real-time in vivo tracking of PNCs can provide critically important information for the development of PNC-based diagnostics and therapeutics. Here we demonstrate a general strategy for monitoring the behaviors of PNCs in vivo by encapsulating a Ag2S quantum dot (QD) with fluorescence in the second near-infrared window (NIR-II, 1000-1700 nm) inside the PNC, using simian virus 40 (SV40) PNC (PNCSV40) as a model. Benefiting from the high spatiotemporal resolution and deep tissue penetration of NIR-II fluorescence imaging, the dynamic distribution of the PNCSV40 in living mice was tracked in real time with high fidelity, and adopting the PEGylation strategy, surface chemistry-dependent in vivo behaviors of PNCSV40 were clearly revealed. This study represents the first evidence of real-time tracking of the intrinsic behaviors of PNCs in vivo without interference in PNC-host interactions by encapsulating nanoprobes inside. The as-described imaging strategy will facilitate the study of interactions between exogenously introduced PNCs and host body and prompt the development of future protein-based drugs, sensors, and high-efficacy targeted delivery systems.
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Citations by publishers
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Li C. et al. Real-Time Monitoring Surface Chemistry-Dependent In Vivo Behaviors of Protein Nanocages via Encapsulating an NIR-II Ag2S Quantum Dot // ACS Nano. 2015. Vol. 9. No. 12. pp. 12255-12263.
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Li C., Li F., Zhang Y., Zhang W., Zhang X., Wang Q. Real-Time Monitoring Surface Chemistry-Dependent In Vivo Behaviors of Protein Nanocages via Encapsulating an NIR-II Ag2S Quantum Dot // ACS Nano. 2015. Vol. 9. No. 12. pp. 12255-12263.
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TY - JOUR
DO - 10.1021/acsnano.5b05503
UR - https://doi.org/10.1021/acsnano.5b05503
TI - Real-Time Monitoring Surface Chemistry-Dependent In Vivo Behaviors of Protein Nanocages via Encapsulating an NIR-II Ag2S Quantum Dot
T2 - ACS Nano
AU - Zhang, Yejun
AU - Zhang, Xian-En
AU - Li, Chunyan
AU - Li, Feng
AU - Zhang, Wenjing
AU - Wang, Qiangbin
PY - 2015
DA - 2015/10/28 00:00:00
PB - American Chemical Society (ACS)
SP - 12255-12263
IS - 12
VL - 9
SN - 1936-0851
SN - 1936-086X
ER -
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@article{2015_Li,
author = {Yejun Zhang and Xian-En Zhang and Chunyan Li and Feng Li and Wenjing Zhang and Qiangbin Wang},
title = {Real-Time Monitoring Surface Chemistry-Dependent In Vivo Behaviors of Protein Nanocages via Encapsulating an NIR-II Ag2S Quantum Dot},
journal = {ACS Nano},
year = {2015},
volume = {9},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/acsnano.5b05503},
number = {12},
pages = {12255--12263},
doi = {10.1021/acsnano.5b05503}
}
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MLA
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Li, Chunyan, et al. “Real-Time Monitoring Surface Chemistry-Dependent In Vivo Behaviors of Protein Nanocages via Encapsulating an NIR-II Ag2S Quantum Dot.” ACS Nano, vol. 9, no. 12, Oct. 2015, pp. 12255-12263. https://doi.org/10.1021/acsnano.5b05503.