Open Access
Antiproliferative Organic Salts Derived from Betulinic Acid: Disclosure of an Ionic Liquid Selective Against Lung and Liver Cancer Cells
Ana Teresa Silva
1
,
Maria João Cerqueira
2
,
Cristina Prudêncio
2, 3
,
M. Fernandes
4, 5
,
João Costa-Rodrigues
2, 3, 5, 6
,
Cátia Teixeira
1
,
P S. C. Gomes
1
,
Ricardo Ferraz
1, 2
1
3
5
Faculdade de Medicina Dentária, U. Porto, Rua Dr. Manuel Pereira da Silva, Porto 4200-393, Portugal
|
Тип публикации: Journal Article
Дата публикации: 2019-03-21
scimago Q1
wos Q2
БС1
SJR: 0.773
CiteScore: 7.1
Impact factor: 4.3
ISSN: 24701343
General Chemistry
General Chemical Engineering
Краткое описание
In the last few years, we have been witnessing an increasing interest in ionic liquids (ILs) and organic salts, given their potential applications in biological and pharmaceutical sciences. We report the synthesis and in vitro evaluation of novel organic salts combining betulinate, known for its anticancer properties, with antimalarial drugs, primaquine, chloroquine, and mepacrine, and also with the trihexyltetradecylphosphonium ([P6,6,6,14]) cation. The salts were screened for their in vitro activity against tumor lines HepG2 (liver), MG63 (osteosarcoma), T47D (breast), A459 (lung), and RKO (colon), and also on normal human fibroblasts. All betulinates prepared displayed antiproliferative properties, with the trihexyltetradecylphosphonium betulinate standing out for its higher selectivity. This unprecedented disclosure of a betulinic acid (BA)-derived IL with selective antitumor activity constitutes a relevant first step toward development of novel anticancer therapies based on BA-derived IL.
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ГОСТ
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Silva A. T. et al. Antiproliferative Organic Salts Derived from Betulinic Acid: Disclosure of an Ionic Liquid Selective Against Lung and Liver Cancer Cells // ACS Omega. 2019. Vol. 4. No. 3. pp. 5682-5689.
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Silva A. T., Cerqueira M. J., Prudêncio C., Fernandes M., Costa-Rodrigues J., Teixeira C., Gomes P. S. C., Ferraz R. Antiproliferative Organic Salts Derived from Betulinic Acid: Disclosure of an Ionic Liquid Selective Against Lung and Liver Cancer Cells // ACS Omega. 2019. Vol. 4. No. 3. pp. 5682-5689.
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TY - JOUR
DO - 10.1021/acsomega.8b03691
UR - https://doi.org/10.1021/acsomega.8b03691
TI - Antiproliferative Organic Salts Derived from Betulinic Acid: Disclosure of an Ionic Liquid Selective Against Lung and Liver Cancer Cells
T2 - ACS Omega
AU - Silva, Ana Teresa
AU - Cerqueira, Maria João
AU - Prudêncio, Cristina
AU - Fernandes, M.
AU - Costa-Rodrigues, João
AU - Teixeira, Cátia
AU - Gomes, P S. C.
AU - Ferraz, Ricardo
PY - 2019
DA - 2019/03/21
PB - American Chemical Society (ACS)
SP - 5682-5689
IS - 3
VL - 4
SN - 2470-1343
ER -
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@article{2019_Silva,
author = {Ana Teresa Silva and Maria João Cerqueira and Cristina Prudêncio and M. Fernandes and João Costa-Rodrigues and Cátia Teixeira and P S. C. Gomes and Ricardo Ferraz},
title = {Antiproliferative Organic Salts Derived from Betulinic Acid: Disclosure of an Ionic Liquid Selective Against Lung and Liver Cancer Cells},
journal = {ACS Omega},
year = {2019},
volume = {4},
publisher = {American Chemical Society (ACS)},
month = {mar},
url = {https://doi.org/10.1021/acsomega.8b03691},
number = {3},
pages = {5682--5689},
doi = {10.1021/acsomega.8b03691}
}
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MLA
Скопировать
Silva, Ana Teresa, et al. “Antiproliferative Organic Salts Derived from Betulinic Acid: Disclosure of an Ionic Liquid Selective Against Lung and Liver Cancer Cells.” ACS Omega, vol. 4, no. 3, Mar. 2019, pp. 5682-5689. https://doi.org/10.1021/acsomega.8b03691.