volume 6 issue 2 pages 2535-2540

Sustainable Synthesis of Polynitroesters in the Freon Medium and their in Vitro Evaluation as Potential Nitric Oxide Donors

Publication typeJournal Article
Publication date2018-01-19
scimago Q1
wos Q1
SJR1.623
CiteScore12.5
Impact factor7.3
ISSN21680485
General Chemistry
General Chemical Engineering
Environmental Chemistry
Renewable Energy, Sustainability and the Environment
Abstract
A highly efficient, safe, and sustainable procedure was developed for the synthesis of various pharmacology-relevant and/or energy-rich nitroesters. It is based on nitration of corresponding alcohols with dinitrogen pentoxide in the liquid 1,1,1,2-tetrafluoroethane medium. The proposed approach is attractive for commercial applications because it offers significant advantages such as mild and clean reaction conditions, low operation pressure, available equipment, scalability, and facile fluid recycling. Structure–NO donor activity correlations were elucidated by an in vitro Griess assay for synthesized nitroesters and the obtained data may be useful for further in vivo experiments.
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GOST Copy
Kuchurov I. V. et al. Sustainable Synthesis of Polynitroesters in the Freon Medium and their in Vitro Evaluation as Potential Nitric Oxide Donors // ACS Sustainable Chemistry and Engineering. 2018. Vol. 6. No. 2. pp. 2535-2540.
GOST all authors (up to 50) Copy
Kuchurov I. V., Arabadzhi S. S., Zharkov M. N., Fershtat L. L., Zlotin S. G. Sustainable Synthesis of Polynitroesters in the Freon Medium and their in Vitro Evaluation as Potential Nitric Oxide Donors // ACS Sustainable Chemistry and Engineering. 2018. Vol. 6. No. 2. pp. 2535-2540.
RIS |
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RIS Copy
TY - JOUR
DO - 10.1021/acssuschemeng.7b04029
UR - https://pubs.acs.org/doi/10.1021/acssuschemeng.7b04029
TI - Sustainable Synthesis of Polynitroesters in the Freon Medium and their in Vitro Evaluation as Potential Nitric Oxide Donors
T2 - ACS Sustainable Chemistry and Engineering
AU - Kuchurov, Ilya V
AU - Arabadzhi, Svetlana S
AU - Zharkov, Mikhail N
AU - Fershtat, Leonid L.
AU - Zlotin, Sergei G
PY - 2018
DA - 2018/01/19
PB - American Chemical Society (ACS)
SP - 2535-2540
IS - 2
VL - 6
SN - 2168-0485
ER -
BibTex |
Cite this
BibTex (up to 50 authors) Copy
@article{2018_Kuchurov,
author = {Ilya V Kuchurov and Svetlana S Arabadzhi and Mikhail N Zharkov and Leonid L. Fershtat and Sergei G Zlotin},
title = {Sustainable Synthesis of Polynitroesters in the Freon Medium and their in Vitro Evaluation as Potential Nitric Oxide Donors},
journal = {ACS Sustainable Chemistry and Engineering},
year = {2018},
volume = {6},
publisher = {American Chemical Society (ACS)},
month = {jan},
url = {https://pubs.acs.org/doi/10.1021/acssuschemeng.7b04029},
number = {2},
pages = {2535--2540},
doi = {10.1021/acssuschemeng.7b04029}
}
MLA
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MLA Copy
Kuchurov, Ilya V., et al. “Sustainable Synthesis of Polynitroesters in the Freon Medium and their in Vitro Evaluation as Potential Nitric Oxide Donors.” ACS Sustainable Chemistry and Engineering, vol. 6, no. 2, Jan. 2018, pp. 2535-2540. https://pubs.acs.org/doi/10.1021/acssuschemeng.7b04029.