Encapsulation of an Adamantane-Doxorubicin Prodrug in pH-Responsive Polysaccharide Capsules for Controlled Release
Тип публикации: Journal Article
Дата публикации: 2012-10-05
scimago Q1
wos Q1
БС1
SJR: 1.921
CiteScore: 14.5
Impact factor: 8.2
ISSN: 19448244, 19448252
PubMed ID:
23009157
General Materials Science
Краткое описание
Supramolecular microcapsules (SMCs) with the drug-loaded wall layers for pH-controlled drug delivery were designed and prepared. By using layer-by-layer (LbL) technique, the SMCs were constructed based on the self-assembly between polyaldenhyde dextran-graft-adamantane (PAD-g-AD) and carboxymethyl dextran-graft-β-CD (CMD-g-β-CD) on CaCO3 particles via host-guest interaction. Simultaneously, adamantine-modified doxorubicin (AD-Dox) was also loaded on the LbL wall via host-guest interaction. The in vitro drug release study was carried out at different pHs. Because the AD groups were linked with PAD (PAD-g-AD) or Dox (AD-Dox) by pH-cleavable hydrazone bonds, AD moieties can be removed under the weak acidic condition, leading to destruction of SMCs and release of Dox. The pH-controlled drug release can enhance the uptake by tumor cells and thus achieve improved cancer therapy efficiency.
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ГОСТ
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Luo G. F. et al. Encapsulation of an Adamantane-Doxorubicin Prodrug in pH-Responsive Polysaccharide Capsules for Controlled Release // ACS applied materials & interfaces. 2012. Vol. 4. No. 10. pp. 5317-5324.
ГОСТ со всеми авторами (до 50)
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Luo G. F., Xu X., Zhang J., Yang J., Gong Yu. H., Qi L., Jia H., Li C., Zhuo R., Zhang X. Encapsulation of an Adamantane-Doxorubicin Prodrug in pH-Responsive Polysaccharide Capsules for Controlled Release // ACS applied materials & interfaces. 2012. Vol. 4. No. 10. pp. 5317-5324.
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TY - JOUR
DO - 10.1021/am301258a
UR - https://doi.org/10.1021/am301258a
TI - Encapsulation of an Adamantane-Doxorubicin Prodrug in pH-Responsive Polysaccharide Capsules for Controlled Release
T2 - ACS applied materials & interfaces
AU - Luo, Guo Feng
AU - Xu, Xiao-Ding
AU - Zhang, Jing
AU - Yang, Juan
AU - Gong, Yu Hui
AU - Qi, Lei
AU - Jia, Huizhen
AU - Li, Cao
AU - Zhuo, Ren-Xi
AU - Zhang, Xianzheng
PY - 2012
DA - 2012/10/05
PB - American Chemical Society (ACS)
SP - 5317-5324
IS - 10
VL - 4
PMID - 23009157
SN - 1944-8244
SN - 1944-8252
ER -
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@article{2012_Luo,
author = {Guo Feng Luo and Xiao-Ding Xu and Jing Zhang and Juan Yang and Yu Hui Gong and Lei Qi and Huizhen Jia and Cao Li and Ren-Xi Zhuo and Xianzheng Zhang},
title = {Encapsulation of an Adamantane-Doxorubicin Prodrug in pH-Responsive Polysaccharide Capsules for Controlled Release},
journal = {ACS applied materials & interfaces},
year = {2012},
volume = {4},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/am301258a},
number = {10},
pages = {5317--5324},
doi = {10.1021/am301258a}
}
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MLA
Скопировать
Luo, Guo Feng, et al. “Encapsulation of an Adamantane-Doxorubicin Prodrug in pH-Responsive Polysaccharide Capsules for Controlled Release.” ACS applied materials & interfaces, vol. 4, no. 10, Oct. 2012, pp. 5317-5324. https://doi.org/10.1021/am301258a.