Encapsulation of an Adamantane-Doxorubicin Prodrug in pH-Responsive Polysaccharide Capsules for Controlled Release
Guo Feng Luo
1
,
Xiao-Ding Xu
1
,
Jing Zhang
1
,
Juan Yang
1
,
Yu Hui Gong
1
,
Lei Qi
1
,
Huizhen Jia
1
,
Cao Li
1
,
Ren-Xi Zhuo
1
,
Publication type: Journal Article
Publication date: 2012-10-05
scimago Q1
wos Q1
SJR: 1.921
CiteScore: 14.5
Impact factor: 8.2
ISSN: 19448244, 19448252
PubMed ID:
23009157
General Materials Science
Abstract
Supramolecular microcapsules (SMCs) with the drug-loaded wall layers for pH-controlled drug delivery were designed and prepared. By using layer-by-layer (LbL) technique, the SMCs were constructed based on the self-assembly between polyaldenhyde dextran-graft-adamantane (PAD-g-AD) and carboxymethyl dextran-graft-β-CD (CMD-g-β-CD) on CaCO3 particles via host-guest interaction. Simultaneously, adamantine-modified doxorubicin (AD-Dox) was also loaded on the LbL wall via host-guest interaction. The in vitro drug release study was carried out at different pHs. Because the AD groups were linked with PAD (PAD-g-AD) or Dox (AD-Dox) by pH-cleavable hydrazone bonds, AD moieties can be removed under the weak acidic condition, leading to destruction of SMCs and release of Dox. The pH-controlled drug release can enhance the uptake by tumor cells and thus achieve improved cancer therapy efficiency.
Found
Nothing found, try to update filter.
Found
Nothing found, try to update filter.
Top-30
Journals
|
1
2
3
4
5
6
|
|
|
ACS applied materials & interfaces
6 publications, 6%
|
|
|
Journal of Materials Chemistry B
4 publications, 4%
|
|
|
Advances in Colloid and Interface Science
3 publications, 3%
|
|
|
International Journal of Pharmaceutics
3 publications, 3%
|
|
|
Advanced Functional Materials
3 publications, 3%
|
|
|
RSC Advances
3 publications, 3%
|
|
|
Materials
2 publications, 2%
|
|
|
Nanoscale Research Letters
2 publications, 2%
|
|
|
Journal of Molecular Structure
2 publications, 2%
|
|
|
Biomaterials
2 publications, 2%
|
|
|
Advanced Materials
2 publications, 2%
|
|
|
ChemistrySelect
2 publications, 2%
|
|
|
Chemical Communications
2 publications, 2%
|
|
|
Organic and Biomolecular Chemistry
2 publications, 2%
|
|
|
Advanced Materials Interfaces
1 publication, 1%
|
|
|
Beilstein Journal of Nanotechnology
1 publication, 1%
|
|
|
Beilstein Journal of Organic Chemistry
1 publication, 1%
|
|
|
Micro and Nano Letters
1 publication, 1%
|
|
|
Chemotherapy
1 publication, 1%
|
|
|
Experimental Biology and Medicine
1 publication, 1%
|
|
|
Molecules
1 publication, 1%
|
|
|
Antibiotics
1 publication, 1%
|
|
|
Polymers
1 publication, 1%
|
|
|
Frontiers in Pharmacology
1 publication, 1%
|
|
|
Molecular Diversity
1 publication, 1%
|
|
|
Scientific Reports
1 publication, 1%
|
|
|
Chinese Journal of Polymer Science (English Edition)
1 publication, 1%
|
|
|
Science China Life Sciences
1 publication, 1%
|
|
|
Journal of Membrane Science
1 publication, 1%
|
|
|
1
2
3
4
5
6
|
Publishers
|
5
10
15
20
25
|
|
|
Elsevier
23 publications, 23%
|
|
|
Wiley
19 publications, 19%
|
|
|
Royal Society of Chemistry (RSC)
15 publications, 15%
|
|
|
American Chemical Society (ACS)
12 publications, 12%
|
|
|
Springer Nature
7 publications, 7%
|
|
|
MDPI
6 publications, 6%
|
|
|
Taylor & Francis
3 publications, 3%
|
|
|
Beilstein-Institut
2 publications, 2%
|
|
|
Institution of Engineering and Technology (IET)
1 publication, 1%
|
|
|
S. Karger AG
1 publication, 1%
|
|
|
SAGE
1 publication, 1%
|
|
|
Frontiers Media S.A.
1 publication, 1%
|
|
|
American Institute of Mathematical Sciences (AIMS)
1 publication, 1%
|
|
|
Annual Reviews
1 publication, 1%
|
|
|
Georg Thieme Verlag KG
1 publication, 1%
|
|
|
Autonomous Non-profit Organization Editorial Board of the journal Uspekhi Khimii
1 publication, 1%
|
|
|
5
10
15
20
25
|
- We do not take into account publications without a DOI.
- Statistics recalculated weekly.
Are you a researcher?
Create a profile to get free access to personal recommendations for colleagues and new articles.
Metrics
100
Total citations:
100
Citations from 2024:
8
(8%)
Cite this
GOST |
RIS |
BibTex |
MLA
Cite this
GOST
Copy
Luo G. F. et al. Encapsulation of an Adamantane-Doxorubicin Prodrug in pH-Responsive Polysaccharide Capsules for Controlled Release // ACS applied materials & interfaces. 2012. Vol. 4. No. 10. pp. 5317-5324.
GOST all authors (up to 50)
Copy
Luo G. F., Xu X., Zhang J., Yang J., Gong Yu. H., Qi L., Jia H., Li C., Zhuo R., Zhang X. Encapsulation of an Adamantane-Doxorubicin Prodrug in pH-Responsive Polysaccharide Capsules for Controlled Release // ACS applied materials & interfaces. 2012. Vol. 4. No. 10. pp. 5317-5324.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/am301258a
UR - https://doi.org/10.1021/am301258a
TI - Encapsulation of an Adamantane-Doxorubicin Prodrug in pH-Responsive Polysaccharide Capsules for Controlled Release
T2 - ACS applied materials & interfaces
AU - Luo, Guo Feng
AU - Xu, Xiao-Ding
AU - Zhang, Jing
AU - Yang, Juan
AU - Gong, Yu Hui
AU - Qi, Lei
AU - Jia, Huizhen
AU - Li, Cao
AU - Zhuo, Ren-Xi
AU - Zhang, Xianzheng
PY - 2012
DA - 2012/10/05
PB - American Chemical Society (ACS)
SP - 5317-5324
IS - 10
VL - 4
PMID - 23009157
SN - 1944-8244
SN - 1944-8252
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2012_Luo,
author = {Guo Feng Luo and Xiao-Ding Xu and Jing Zhang and Juan Yang and Yu Hui Gong and Lei Qi and Huizhen Jia and Cao Li and Ren-Xi Zhuo and Xianzheng Zhang},
title = {Encapsulation of an Adamantane-Doxorubicin Prodrug in pH-Responsive Polysaccharide Capsules for Controlled Release},
journal = {ACS applied materials & interfaces},
year = {2012},
volume = {4},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/am301258a},
number = {10},
pages = {5317--5324},
doi = {10.1021/am301258a}
}
Cite this
MLA
Copy
Luo, Guo Feng, et al. “Encapsulation of an Adamantane-Doxorubicin Prodrug in pH-Responsive Polysaccharide Capsules for Controlled Release.” ACS applied materials & interfaces, vol. 4, no. 10, Oct. 2012, pp. 5317-5324. https://doi.org/10.1021/am301258a.