pH optimization of nucleophilic reactions in water
Publication type: Journal Article
Publication date: 1992-04-01
scimago Q1
wos Q1
SJR: 5.554
CiteScore: 22.5
Impact factor: 15.6
ISSN: 00027863, 15205126
General Chemistry
Catalysis
Biochemistry
Colloid and Surface Chemistry
Abstract
We present a way of prwcribing the pH for a reaction so as to obtain either (a) maximum yield in competition with hydrolysis or (b) selective reaction at either of two sites in such nucleophile-electrophile reactions as C-alkylation of acid ketones and the acylation and sulfonylation of amines. First, we derive the following general equation for pH max , the pH giving the highest yield of the product (P) of the reaction of a nucleophile (Nu) with a hydrolyzable electrophile (E) in water
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48
Total citations:
48
Citations from 2025:
1
(2.08%)
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MLA
Cite this
GOST
Copy
KING J. F. et al. pH optimization of nucleophilic reactions in water // Journal of the American Chemical Society. 1992. Vol. 114. No. 8. pp. 3028-3033.
GOST all authors (up to 50)
Copy
KING J. F., Rathore R. P. S., Lam J. Y. L., Guo Z., Klassen D. F. pH optimization of nucleophilic reactions in water // Journal of the American Chemical Society. 1992. Vol. 114. No. 8. pp. 3028-3033.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/ja00034a040
UR - https://doi.org/10.1021/ja00034a040
TI - pH optimization of nucleophilic reactions in water
T2 - Journal of the American Chemical Society
AU - KING, J F
AU - Rathore, R. P. S.
AU - Lam, J Y L
AU - Guo, Z.R.
AU - Klassen, D F
PY - 1992
DA - 1992/04/01
PB - American Chemical Society (ACS)
SP - 3028-3033
IS - 8
VL - 114
SN - 0002-7863
SN - 1520-5126
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1992_KING,
author = {J F KING and R. P. S. Rathore and J Y L Lam and Z.R. Guo and D F Klassen},
title = {pH optimization of nucleophilic reactions in water},
journal = {Journal of the American Chemical Society},
year = {1992},
volume = {114},
publisher = {American Chemical Society (ACS)},
month = {apr},
url = {https://doi.org/10.1021/ja00034a040},
number = {8},
pages = {3028--3033},
doi = {10.1021/ja00034a040}
}
Cite this
MLA
Copy
KING, J. F., et al. “pH optimization of nucleophilic reactions in water.” Journal of the American Chemical Society, vol. 114, no. 8, Apr. 1992, pp. 3028-3033. https://doi.org/10.1021/ja00034a040.