Journal of the American Chemical Society

, том 109 , издание 7 , страницы 2171-2173

The separation of the intramolecular isotope effect for the cytochrome P-450 catalyzed hydroxylation of n-octane into its primary and secondary components

Тип публикации: Journal Article

Дата публикации: 1987-04-01

American Chemical Society (ACS)

Journal of the American Chemical Society

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SJR: 5.491

CiteScore: 22

Impact factor: 16.6

ISSN: 00027863, 15205126

DOI: 10.1021/ja00241a040

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General Chemistry

Catalysis

Biochemistry

Colloid and Surface Chemistry

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The intramolecular isotope effect for the cytochrome P-450b omega-hydroxylation of (1,1,1-/sup 2/H/sub 3/)-n-octane was separated into its primary and secondary components by the method of Hanzlik. The primary isotope effect was found to lie between 7.3 and 7.9 while the secondary isotope effect was found to lie between 1.09 and 1.14. These data are consistent with a highly symmetrical transition state with 15% of the observed isotope effect being due to secondary isotope effects. Although the system was found to depart from the rule of the geometric mean, the phenomenon could not be attributed to tunneling.

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Jones J. P., Trager W. F. The separation of the intramolecular isotope effect for the cytochrome P-450 catalyzed hydroxylation of n-octane into its primary and secondary components // Journal of the American Chemical Society. 1987. Vol. 109. No. 7. pp. 2171-2173.

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TY - JOUR

DO - 10.1021/ja00241a040

UR - https://doi.org/10.1021/ja00241a040

TI - The separation of the intramolecular isotope effect for the cytochrome P-450 catalyzed hydroxylation of n-octane into its primary and secondary components

T2 - Journal of the American Chemical Society

AU - Jones, Jefferey P.

AU - Trager, William F.

PY - 1987

DA - 1987/04/01

PB - American Chemical Society (ACS)

SP - 2171-2173

IS - 7

VL - 109

SN - 0002-7863

SN - 1520-5126

ER -

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@article{1987_Jones,

author = {Jefferey P. Jones and William F. Trager},

title = {The separation of the intramolecular isotope effect for the cytochrome P-450 catalyzed hydroxylation of n-octane into its primary and secondary components},

journal = {Journal of the American Chemical Society},

year = {1987},

volume = {109},

publisher = {American Chemical Society (ACS)},

month = {apr},

url = {https://doi.org/10.1021/ja00241a040},

number = {7},

pages = {2171--2173},

doi = {10.1021/ja00241a040}

}

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Jones, Jefferey P., and William F. Trager. “The separation of the intramolecular isotope effect for the cytochrome P-450 catalyzed hydroxylation of n-octane into its primary and secondary components.” Journal of the American Chemical Society, vol. 109, no. 7, Apr. 1987, pp. 2171-2173. https://doi.org/10.1021/ja00241a040.

Издатель

American Chemical Society (ACS)

Журнал

Journal of the American Chemical Society

SCImago Q1

Tоп 10% SCImago

WOS Q1

БС1