Asymmetric total synthesis of erythromycin. 2. Synthesis of an erythronolide A lactone system
Publication type: Journal Article
Publication date: 1981-06-01
scimago Q1
wos Q1
SJR: 5.554
CiteScore: 22.5
Impact factor: 15.6
ISSN: 00027863, 15205126
General Chemistry
Catalysis
Biochemistry
Colloid and Surface Chemistry
Abstract
In reporting a total synthesis of erythromycin (la) we described in the preceding paper1 the synthesis of the erythronolide A seco acid derivative 2 in optically active form. In this paper we wish to report a successful transformation of 2 to 12 (synthetically equivalent to erythronolide A) via lactonization and also demonstrate that the proper functionalization of a substrate is critical for the successful lactonization.
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157
Total citations:
157
Citations from 2024:
3
(1.91%)
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MLA
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GOST
Copy
Woodward R. B. et al. Asymmetric total synthesis of erythromycin. 2. Synthesis of an erythronolide A lactone system // Journal of the American Chemical Society. 1981. Vol. 103. No. 11. pp. 3213-3215.
GOST all authors (up to 50)
Copy
Woodward R. B., Ward D. E., Au Yeung B. W., Balaram P., Browne L. J., Card P. J., Chen C. H. Asymmetric total synthesis of erythromycin. 2. Synthesis of an erythronolide A lactone system // Journal of the American Chemical Society. 1981. Vol. 103. No. 11. pp. 3213-3215.
Cite this
RIS
Copy
TY - JOUR
DO - 10.1021/ja00401a050
UR - https://doi.org/10.1021/ja00401a050
TI - Asymmetric total synthesis of erythromycin. 2. Synthesis of an erythronolide A lactone system
T2 - Journal of the American Chemical Society
AU - Woodward, R B
AU - Ward, D. E.
AU - Au Yeung, B W
AU - Balaram, P
AU - Browne, L J
AU - Card, P. J.
AU - Chen, C H
PY - 1981
DA - 1981/06/01
PB - American Chemical Society (ACS)
SP - 3213-3215
IS - 11
VL - 103
SN - 0002-7863
SN - 1520-5126
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{1981_Woodward,
author = {R B Woodward and D. E. Ward and B W Au Yeung and P Balaram and L J Browne and P. J. Card and C H Chen},
title = {Asymmetric total synthesis of erythromycin. 2. Synthesis of an erythronolide A lactone system},
journal = {Journal of the American Chemical Society},
year = {1981},
volume = {103},
publisher = {American Chemical Society (ACS)},
month = {jun},
url = {https://doi.org/10.1021/ja00401a050},
number = {11},
pages = {3213--3215},
doi = {10.1021/ja00401a050}
}
Cite this
MLA
Copy
Woodward, R. B., et al. “Asymmetric total synthesis of erythromycin. 2. Synthesis of an erythronolide A lactone system.” Journal of the American Chemical Society, vol. 103, no. 11, Jun. 1981, pp. 3213-3215. https://doi.org/10.1021/ja00401a050.