DNA Damage by Fasicularin
Publication type: Journal Article
Publication date: 2005-10-11
scimago Q1
wos Q1
SJR: 5.554
CiteScore: 22.5
Impact factor: 15.6
ISSN: 00027863, 15205126
PubMed ID:
16248621
General Chemistry
Catalysis
Biochemistry
Colloid and Surface Chemistry
Abstract
Fasicularin is a structurally novel thiocyanate-containing alkaloid isolated from the ascidian Nephteis fasicularis. Early biological experiments suggested that this compound's cytotoxic properties may stem from its ability to damage cellular DNA. Sequence gel analysis reveals that treatment of a 5‘-32P-labeled DNA duplex with fasicularin in pH 7.0 buffer causes strand cleavage selectively at guanine residues. Further experiments indicate that production of these base-labile lesions in DNA involves alkylation of guanine residues by a fasicularin-derived aziridinium ion. This work reveals fasicularin as the first natural product found to generate a DNA-alkylating aziridinium ion via a mechanism analogous to the clinically used anticancer drugs mechlorethamine, melphalan, and chlorambucil.
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Metrics
170
Total citations:
170
Citations from 2025:
15
(8.83%)
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GOST
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Dutta S. K. et al. DNA Damage by Fasicularin // Journal of the American Chemical Society. 2005. Vol. 127. No. 43. pp. 15004-15005.
GOST all authors (up to 50)
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Dutta S. K., Abe H., AOYAGI S., Kibayashi C., Gates K. S. DNA Damage by Fasicularin // Journal of the American Chemical Society. 2005. Vol. 127. No. 43. pp. 15004-15005.
Cite this
RIS
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TY - JOUR
DO - 10.1021/ja053735i
UR - https://doi.org/10.1021/ja053735i
TI - DNA Damage by Fasicularin
T2 - Journal of the American Chemical Society
AU - Dutta, Sanjay K.
AU - Abe, Hideki
AU - AOYAGI, SAKAE
AU - Kibayashi, Chihiro
AU - Gates, Kent S.
PY - 2005
DA - 2005/10/11
PB - American Chemical Society (ACS)
SP - 15004-15005
IS - 43
VL - 127
PMID - 16248621
SN - 0002-7863
SN - 1520-5126
ER -
Cite this
BibTex (up to 50 authors)
Copy
@article{2005_Dutta,
author = {Sanjay K. Dutta and Hideki Abe and SAKAE AOYAGI and Chihiro Kibayashi and Kent S. Gates},
title = {DNA Damage by Fasicularin},
journal = {Journal of the American Chemical Society},
year = {2005},
volume = {127},
publisher = {American Chemical Society (ACS)},
month = {oct},
url = {https://doi.org/10.1021/ja053735i},
number = {43},
pages = {15004--15005},
doi = {10.1021/ja053735i}
}
Cite this
MLA
Copy
Dutta, Sanjay K., et al. “DNA Damage by Fasicularin.” Journal of the American Chemical Society, vol. 127, no. 43, Oct. 2005, pp. 15004-15005. https://doi.org/10.1021/ja053735i.