Biocleavable Polyrotaxane−Plasmid DNA Polyplex for Enhanced Gene Delivery
Tooru Ooya
1
,
Hak Yong Choi
1
,
Atsushi Yamashita
1
,
Nobuhiko Yui
1
,
Yuko Sugaya
1
,
Arihiro Kano
1
,
Atsushi Maruyama
1
,
Hidetaka Akita
1
,
Rie Ito
1
,
Kentaro Kogure
1
,
Hideyoshi Harashima
1
Publication type: Journal Article
Publication date: 2006-03-01
scimago Q1
wos Q1
SJR: 5.554
CiteScore: 22.5
Impact factor: 15.6
ISSN: 00027863, 15205126
PubMed ID:
16551060
General Chemistry
Catalysis
Biochemistry
Colloid and Surface Chemistry
Abstract
A biocleavable polyrotaxane, having a necklace-like structure consisting of many cationic alpha-cyclodextrins (alpha-CDs) and a disulfide-introduced poly(ethylene glycol) (PEG), was synthesized and examined as a nonviral gene carrier. The polyrotaxane formed a stable polyplex having positively charged surface even at low charge ratio. This is likely to be due to structural factors of the polyrotaxane, such as the mobile motion of alpha-CDs in the necklace-like structure. Rapid endosomal escape was observed 90 min after transfection. The positively charged surface and the good buffering capacity are advantageous to show the proton sponge effect. The pDNA decondensation occurred through disulfide cleavage of the polyrotaxane and subsequent supramolecular dissociation of the noncovalent linkages between alpha-CDs and PEG. Transfection of the DMAE-SS-PRX polyplex is independent of the amount of free polycation. Those properties played a key role for delivery of pDNA clusters to the nucleus. Therefore, the polyplex nature and the supramolecular dissociation of the polyrotaxane contributed to the enhanced gene delivery.
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Total citations:
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Citations from 2025:
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GOST
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Ooya T. et al. Biocleavable Polyrotaxane−Plasmid DNA Polyplex for Enhanced Gene Delivery // Journal of the American Chemical Society. 2006. Vol. 128. No. 12. pp. 3852-3853.
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Ooya T., Choi H. Y., Yamashita A., Yui N., Sugaya Y., Kano A., Maruyama A., Akita H., Ito R., Kogure K., Harashima H. Biocleavable Polyrotaxane−Plasmid DNA Polyplex for Enhanced Gene Delivery // Journal of the American Chemical Society. 2006. Vol. 128. No. 12. pp. 3852-3853.
Cite this
RIS
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TY - JOUR
DO - 10.1021/ja055868+
UR - https://doi.org/10.1021/ja055868
TI - Biocleavable Polyrotaxane−Plasmid DNA Polyplex for Enhanced Gene Delivery
T2 - Journal of the American Chemical Society
AU - Ooya, Tooru
AU - Choi, Hak Yong
AU - Yamashita, Atsushi
AU - Yui, Nobuhiko
AU - Sugaya, Yuko
AU - Kano, Arihiro
AU - Maruyama, Atsushi
AU - Akita, Hidetaka
AU - Ito, Rie
AU - Kogure, Kentaro
AU - Harashima, Hideyoshi
PY - 2006
DA - 2006/03/01
PB - American Chemical Society (ACS)
SP - 3852-3853
IS - 12
VL - 128
PMID - 16551060
SN - 0002-7863
SN - 1520-5126
ER -
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@article{2006_Ooya,
author = {Tooru Ooya and Hak Yong Choi and Atsushi Yamashita and Nobuhiko Yui and Yuko Sugaya and Arihiro Kano and Atsushi Maruyama and Hidetaka Akita and Rie Ito and Kentaro Kogure and Hideyoshi Harashima},
title = {Biocleavable Polyrotaxane−Plasmid DNA Polyplex for Enhanced Gene Delivery},
journal = {Journal of the American Chemical Society},
year = {2006},
volume = {128},
publisher = {American Chemical Society (ACS)},
month = {mar},
url = {https://doi.org/10.1021/ja055868 },
number = {12},
pages = {3852--3853},
doi = {10.1021/ja055868+}
}
Cite this
MLA
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Ooya, Tooru, et al. “Biocleavable Polyrotaxane−Plasmid DNA Polyplex for Enhanced Gene Delivery.” Journal of the American Chemical Society, vol. 128, no. 12, Mar. 2006, pp. 3852-3853. https://doi.org/10.1021/ja055868 .